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Glycine Transporter 1

National Institutes of Health

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glycine transporter

Papers overview

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2011
2011
Synthesis and biological evaluation of 3-biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as novel glycine transporter 1 inhibitors.
We describe the preparation and evaluation of a novel series of glycine transporter 1 (GlyT1) inhibitors derived from a high… 
2011
2011
The synthesis and preclinical evaluation in rhesus monkey of [18F]MK‐6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers
Two positron emission tomography radiotracers for the glycine transporter 1 (GlyT1) are reported here. Each radiotracer is a… 
Review
2010
Review
2010
Functional 'glial' GLYT1 glycine transporters expressed in neurons.
Glycine transporter 1 (GLYT1) and GLYT2 are the glycine transporters in CNS. While GLYT2 is largely expressed in glycinergic… 
2010
2010
Alterations in the hippocampal glycinergic system in an animal model of posttraumatic stress disorder.
Highly Cited
2008
Highly Cited
2008
Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas
2008
2008
The glycine transporter 1 inhibitor SSR504734 enhances working memory performance in a continuous delayed alternation task in C57BL/6 mice
RationaleInhibition of the glycine transporter 1 (GlyT1) activity increases extra-cellular glycine availability in the CNS. At… 
Highly Cited
2006
Highly Cited
2006
The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats.
UNLABELLED Previous findings from our group indicate that accumbal glycine receptors (GlyRs) are involved in mediating the… 
Highly Cited
2004
Highly Cited
2004
Characterization of an amacrine cell type of the mammalian retina immunoreactive for vesicular glutamate transporter 3
Immunocytochemical staining of vertical sections through rat, mouse, and macaque monkey retinae with antibodies against the… 
2004
2004
The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors.
Highly Cited
2001
Highly Cited
2001
ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter.
High-affinity glycine transport in neurons and glial cells is a primary means of inactivating synaptic glycine. We have… 
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