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Glycine Chenodeoxycholate

Known as: Chenodeoxycholate, Glycine, Glycochenodeoxycholate 
National Institutes of Health

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Glycochenodeoxycholic Acid

Papers overview

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Highly Cited
2012
Highly Cited
2012
Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry.
Rheumatoid arthritis (RA) is the most severe type of chronic inflammatory disease and has always been a research hotspot in… 
Highly Cited
2003
Highly Cited
2003
Bile Acids Stimulate cFLIP Phosphorylation Enhancing TRAIL-mediated Apoptosis*
Bile acids induce hepatocyte injury by enhancing death receptor-mediated apoptosis. In this study, bile acid effects on TRAIL… 
Highly Cited
2001
Highly Cited
2001
The Bile Acid Glycochenodeoxycholate Induces TRAIL-Receptor 2/DR5 Expression and Apoptosis*
Toxic bile salts induce hepatocyte apoptosis by both Fas-dependent and -independent mechanisms. In this study, we examined the… 
Highly Cited
2000
Highly Cited
2000
Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas.
Toxic bile salts induce hepatocyte apoptosis by a Fas-dependent, Fas ligand-independent mechanism. To account for this… 
Review
1998
Review
1998
Induction of the mitochondrial permeability transition as a mechanism of liver injury during cholestasis: a potential role for mitochondrial proteases.
Highly Cited
1997
Highly Cited
1997
Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes.
BACKGROUND & AIMS Bile salt-induced apoptosis is mediated by a trypsin-like nuclear protease. The aims of this study were to… 
Highly Cited
1995
Highly Cited
1995
Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection.
Ursodeoxycholate (UDCA), a hydrophilic bile salt, ameliorates hepatocellular injury by toxic bile salts and is used to treat… 
Highly Cited
1993
Highly Cited
1993
Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium.
Chenodeoxycholate is toxic to hepatocytes, and accumulation of chenodeoxycholate in the liver during cholestasis may potentiate… 
Highly Cited
1990
Highly Cited
1990
Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes
Primary human hepatocytes were used to study bile salt hepatotoxicity and the hepatoprotective potential of ursodeoxycholate in… 
Highly Cited
1968
Highly Cited
1968
Bile-salts in small intestinal contents after ileal resection and in other malabsorption syndromes.
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