Glutaminase Family

Known as: L-Glutamine Amidohydrolase, L-Glutamine Amidohydrolase Family, Glutaminase I 
An enzyme family that cleaves amide bonds to generate glutamate from glutamine. There are two human glutaminase genes that are expressed in a tissue… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1963-2017
051019632017

Papers overview

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2015
2015
Cancer cells require glutamine to adapt to increased biosynthetic activity. The limiting step in intracellular glutamine… (More)
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2014
2014
Growth-promoting signaling molecules, including the mammalian target of rapamycin complex 1 (mTORC1), drive the metabolic… (More)
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Highly Cited
2013
Highly Cited
2013
Glutaminase 1 is the main enzyme responsible for glutamate production in mammalian cells. The roles of macrophage and microglia… (More)
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Highly Cited
2010
Highly Cited
2010
Mutation at the R132 residue of isocitrate dehydrogenase 1 (IDH1), frequently found in gliomas and acute myelogenous leukemia… (More)
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Highly Cited
2009
Highly Cited
2009
Altered glucose metabolism in cancer cells is termed the Warburg effect, which describes the propensity of most cancer cells to… (More)
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Highly Cited
2009
Highly Cited
2009
Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system… (More)
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2008
2008
We have shown previously, that the most neurotoxic factor from activated microglia is glutamate that is produced by glutaminase… (More)
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Highly Cited
1999
Highly Cited
1999
Three human glutaminase (hGA) isoforms were identified, two of which represent isoforms previously unidentified in any species… (More)
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1995
1995
Gabapentin is a novel anticonvulsant drug. The anticonvulsant mechanism of gabapentin is not known. Based on the amino acid… (More)
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1989
1989
Rats were fed a standard diet or the standard diet supplemented with ammonium acetate (20% w/w) for up to 100 days. The effect of… (More)
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