Gluconeogenesis

Known as: Gluconeogenic Process, glucose biosynthesis, glucose biosynthetic process 
The biosynthesis of new glucose as opposed to that generated by the metabolism of glycogen. Gluconeogenesis occurs mainly in the liver or kidneys… (More)
National Institutes of Health

Related topics

Related topics

33 relations
ADIPOQ geneADIPOQ wt AlleleAlanine Aminotransferase 1, humanAlanine Aminotransferase 2, human
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Broader (2)

carbohydrate biosynthetic processglucose metabolism

Papers overview

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Highly Cited
2014
Highly Cited
2014
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
Metformin is considered to be one of the most effective therapeutics for treating type 2 diabetes because it specifically reduces… (More)
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Highly Cited
2010
Highly Cited
2010
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.
Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein… (More)
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Highly Cited
2010
Highly Cited
2010
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.
The livers of insulin-resistant, diabetic mice manifest selective insulin resistance, suggesting a bifurcation in the insulin… (More)
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Highly Cited
2008
Highly Cited
2008
A Fasting Inducible Switch Modulates Gluconeogenesis Via Activator-Coactivator Exchange
During early fasting, increases in skeletal muscle proteolysis liberate free amino acids for hepatic gluconeogenesis in response… (More)
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Highly Cited
2003
Highly Cited
2003
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
Hepatic gluconeogenesis is absolutely required for survival during prolonged fasting or starvation, but is inappropriately… (More)
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Highly Cited
2003
Highly Cited
2003
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Hepatic gluconeogenesis is absolutely required for survival during prolonged fasting or starvation, but is inappropriately… (More)
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Highly Cited
2002
Highly Cited
2002
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism. However… (More)
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Highly Cited
2001
Highly Cited
2001
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and glucose secretion by the… (More)
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Highly Cited
2001
Highly Cited
2001
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
When mammals fast, glucose homeostasis is achieved by triggering expression of gluconeogenic genes in response to glucagon and… (More)
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Highly Cited
1996
Highly Cited
1996
Contributions of gluconeogenesis to glucose production in the fasted state.
Healthy subjects ingested 2H2O and after 14, 22, and 42 h of fasting the enrichments of deuterium in the hydrogens bound to… (More)
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