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Gleason Pattern 4 (classification)

Known as: Gleason Grade 4, Gleason Pattern 4 
A pattern of prostate carcinoma characterized by the presence of fused, cribriform, or poorly defined glands. There is partial loss of normal… 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Not all gleason pattern 4 prostate cancers are created equal: A study of latent prostatic carcinomas in a cystoprostatectomy and autopsy series
The Gleason grading system represents the cornerstone of the management of prostate cancer. Gleason grade 4 (G4) is a… 
Highly Cited
2014
Highly Cited
2014
Gleason Score 3 + 4=7 Prostate Cancer With Minimal Quantity of Gleason Pattern 4 on Needle Biopsy Is Associated With Low-risk Tumor in Radical Prostatectomy Specimen
A modified Gleason grading system as proposed in the 2005 International Society of Urological Pathology (ISUP) consensus meeting… 
Review
2010
Review
2010
An update of the Gleason grading system.
Highly Cited
2009
Highly Cited
2009
Gleason grading of prostatic adenocarcinoma with glomeruloid features on needle biopsy.
Highly Cited
2008
Highly Cited
2008
Low testosterone and risk of biochemical recurrence and poorly differentiated prostate cancer at radical prostatectomy.
Highly Cited
2007
Highly Cited
2007
Immunohistochemical Antibody Cocktail Staining (p63/HMWCK/AMACR) of Ductal Adenocarcinoma and Gleason Pattern 4 Cribriform and Noncribriform Acinar Adenocarcinomas of the Prostate
Overexpression of alpha-methylacyl coenzyme A racemase (AMACR) in combination with absence of basal cell markers [ie, p63 and… 
Highly Cited
2006
Highly Cited
2006
Evidence for a biopsy derived grade artifact among larger prostate glands.
Highly Cited
2002
Highly Cited
2002
Down-regulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition.
Many cancers have altered expression of various cell adhesion molecules. One of these is CEACAM1, which has been found to be… 
Review
2002
Review
2002
Percent prostate needle biopsy tissue with cancer is more predictive of biochemical failure or adverse pathology after radical prostatectomy than prostate specific antigen or Gleason score.
Highly Cited
1999
Highly Cited
1999
Clinical predictors of upgrading to Gleason grade 4 or 5 disease at radical prostatectomy: potential implications for patient selection for radiation and androgen suppression therapy.
PURPOSE A survival benefit has been suggested by the Radiation Therapy Oncology Group (RTOG) for the addition of androgen… 
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