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Germline Genotype Testing

Known as: Germline Genotype Analysis, Germline Genotyping 
An assay used to determine the genes and molecular markers present in the germline DNA of an individual.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Clinical Implications of Real-time Integrative Sequencing in Management of Patients With Suspected Germline BAP1 Mutations.
Germline mutation of BRCA-associated protein-1 has been implicated in the development of tumor predisposition syndrome and high… 
2018
2018
Abstract CT050: A phase I dose escalation study of BGB-290 in Chinese subjects with advanced ovarian, fallopian, and primary peritoneal, or advanced triple-negative breast cancer
Background BGB-290 is a selective inhibitor of poly (ADP-ribose) polymerases (PARP) 1 and 2 that crosses the blood-brain barrier… 
Review
2017
Review
2017
Abstract P3-09-05: Clinical outcome of patients with advanced triple negative breast cancer with germline and somatic variants in homologous recombination gene
Background: Variants in homologous recombination (HR) genes other than BRCA1/2 may cause a BRCA -like phenotype triple negative… 
2017
2017
Retraction: Suppression of intestinal tumorigenesis in Apc mutant mice upon Musashi-1 deletion. J. Cell Sci. doi: 10.1242/jcs.197574
The journal is retracting ‘Suppression of intestinal tumorigenesis in  Apc  mutant mice upon Musashi-1 deletion’ by Andy R. Wolfe… 
Highly Cited
2015
Highly Cited
2015
Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection
Genome editing technologies, especially the Cas9/CRISPR system, have revolutionized biomedical research over the past several… 
Review
2015
Review
2015
Oncotype DX in BRCA-associated vs. sporadic breast cancers: Differences based on germline mutation status and potential implications for adjuvant systemic therapy (AST).
519 Background: Biological differences between BRCA-associated and sporadic breast cancer (BC) could warrant different… 
2013
2013
Germline and somatic KLLN alterations in breast cancer dysregulate G2 arrest.
PTEN is a well-described predisposition gene for Cowden syndrome (CS), a familial cancer syndrome characterized by a high risk of… 
2008
2008
Genome-Wide Analysis of Germline CNPs and SNPs in Prostate Cancer
Abstract : Prostate cancer (PCa) is the leading cancer among men in the United States, and is a disease with strong genetic… 
Review
2008
Review
2008
Can genetic testing guide treatment in breast cancer?
Review
2002
Review
2002
Report of 16 kindreds and one kindred with hMLH1 germline mutation.
AIM To analyze the diagnosis and treatment of 16 hereditary nonpolyposis colorectal cancer (HNPCC) kindreds, and to report the… 
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