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Genomic Instability

Known as: genomes instability, Genomic Instabilities, Instabilities, Genome 
A biological process consisting of chromosomal rearrangements and duplications. These phenotypes are often seen in the karyotype of cancer cells… 
National Institutes of Health

Related topics

Related topics

5 relations
ChromothripsisDNA Sequence, UnstableGenomic Stabilityaspects of radiation effects

Papers overview

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Highly Cited
2009
Highly Cited
2009
Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment.
Disruption of replication can lead to loss of genome integrity and increase of cancer susceptibility in mammals. Thus, a… 
Highly Cited
2008
Highly Cited
2008
Non-linear pulsations in Wolf-Rayet stars
Numerical simulations of the evolution of strange-mode instabilities into the non-linear regime have been performed for a wide… 
Review
2006
Review
2006
The offspring of irradiated parents, are they stable?
Highly Cited
2006
Highly Cited
2006
Analysis of gross-chromosomal rearrangements in Saccharomyces cerevisiae.
Highly Cited
2004
Highly Cited
2004
Checkpoint-mediated control of replisome–fork association and signalling in response to replication pausing
The replication checkpoint controls the integrity of replicating chromosomes by stabilizing stalled forks, thus preventing the… 
Highly Cited
2001
Highly Cited
2001
Opposite roles of ERK and p38 mitogen-activated protein kinases in cadmium-induced genotoxicity and mitotic arrest.
The roles of extracellular signal-regulated kinase (ERK) and p38 mitogen-activation protein kinase (MAPK) in guarding genome… 
Highly Cited
2000
Highly Cited
2000
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress.
The eukaryotic cell cycle is overseen by regulatory mechanisms, termed checkpoints, that respond to DNA damage, mitotic spindle… 
Review
1999
Review
1999
Regulated genomic instability and neoplasia in the lymphoid lineage.
A DAPTIVE IMMUNITY in mammals depends on the generation of a vast repertoire of Ig and T-cell receptor (TCR) specificities… 
Review
1998
Review
1998
Evolution by polyploidy in Amphibia: new insights
Polyploidy is an important mechanism of evolution in lower vertebrates, resulting in gene duplication and loci duplication… 
Highly Cited
1992
Highly Cited
1992
Interlocus V-J recombination measures genomic instability in agriculture workers at risk for lymphoid malignancies.
V(D)J [variable-(diversity)-joining] rearrangements occur between, as well as within, immune receptor loci, resulting in the… 
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