Genomic Instability

Known as: genomes instability, Genomic Instabilities, Instabilities, Genome 
A biological process consisting of chromosomal rearrangements and duplications. These phenotypes are often seen in the karyotype of cancer cells… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The shortening of human telomeres has two opposing effects during cancer development. On the one hand, telomere shortening can… (More)
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Review
2011
Review
2011
The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The… (More)
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Highly Cited
2011
Highly Cited
2011
Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To… (More)
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Review
2010
Review
2010
Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic instability results from mutations in DNA… (More)
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Highly Cited
2008
Highly Cited
2008
Genomic instability and alterations in gene expression are hallmarks of eukaryotic aging. The yeast histone deacetylase Sir2… (More)
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Highly Cited
2005
Highly Cited
2005
DNA damage checkpoint genes, such as p53, are frequently mutated in human cancer, but the selective pressure for their… (More)
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Highly Cited
2005
Highly Cited
2005
Premature aging syndromes often result from mutations in nuclear proteins involved in the maintenance of genomic integrity. Lamin… (More)
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Review
2004
Review
2004
Colorectal cancer affected ∼135,000 people in the United States in 2001, resulting in 57,000 deaths. At the cellular level… (More)
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Review
2004
Review
2004
Polyploidy is a frequent phenomenon in the eukaryotic world, but the biological properties of polyploid cells are not well… (More)
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Review
2004
Review
2004
Genomic instability is intrinsically linked to significant alterations in apoptosis control. Chromosomal and microsatellite… (More)
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