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Genomic Instability

Known as: genomes instability, Genomic Instabilities, Instabilities, Genome 
A biological process consisting of chromosomal rearrangements and duplications. These phenotypes are often seen in the karyotype of cancer cells… 
National Institutes of Health

Related topics

Related topics

5 relations
ChromothripsisDNA Sequence, UnstableGenomic Stabilityaspects of radiation effects

Papers overview

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Review
2012
Review
2012
The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art.
Highly Cited
2011
Highly Cited
2011
Aneuploidy Drives Genomic Instability in Yeast
Extra chromosomes cause general genomic instability in yeast. Aneuploidy decreases cellular fitness, yet it is also associated… 
Highly Cited
2006
Highly Cited
2006
Breast tumor copy number aberration phenotypes and genomic instability
BackgroundGenomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal… 
Highly Cited
2002
Highly Cited
2002
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form γ-H2AX… 
Highly Cited
2002
Highly Cited
2002
ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones
Budding yeast Mec1, homolog of mammalian ATR, is an essential protein that mediates S-phase checkpoint responses and meiotic… 
Review
2002
Review
2002
ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage.
Highly Cited
2002
Highly Cited
2002
Mitochondrial dysfunction leads to telomere attrition and genomic instability
Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence, apoptosis, aging and aging‐associated… 
Highly Cited
2001
Highly Cited
2001
Mutation in Brca2 stimulates error‐prone homology‐directed repair of DNA double‐strand breaks occurring between repeated sequences
Mutation of BRCA2 causes familial early onset breast and ovarian cancer. BRCA2 has been suggested to be important for the… 
Review
1996
Review
1996
Genomic instability induced by ionizing radiation.
Genomic instability is characterized by the increased rate of acquisition of alterations in the mammalian genome. These changes… 
Highly Cited
1994
Highly Cited
1994
Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation
Genomic instability at simple repeated sequences (SRS) is a landmark for some sporadic and hereditary cancers of the colon. We… 
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