Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Genetically Engineered Mouse

Known as: GEM 
A mouse that has been genetically modified by introducing new genetic characteristics to it. It often involves the isolation, manipulation and… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Genetically engineered mouse models of melanoma.
Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
Is this relevant?
Highly Cited
2016
Highly Cited
2016
Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma
Significance Knowledge of oncogenic alterations that drive lung adenocarcinoma formation has enabled the development of… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Review
2015
Review
2015
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths, and overall survival has not changed… Expand
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2013
Highly Cited
2013
Novel Pancreatic Cancer Cell Lines Derived from Genetically Engineered Mouse Models of Spontaneous Pancreatic Adenocarcinoma: Applications in Diagnosis and Therapy
Pancreatic cancer (PC) remains one of the most lethal human malignancies with poor prognosis. Despite all advances in preclinical… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2011
Highly Cited
2011
The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer
Purpose To examine the in vitro and in vivo efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2011
Highly Cited
2011
BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity
The properties of breast cancer susceptibility protein required for tumor suppression have been explored. Germline mutations of… Expand
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment
Most genetically engineered mouse (GEM) models for colon cancer are based on tissuewide or germline gene modification, resulting… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development
Background The complexity and heterogeneity of the human plasma proteome have presented significant challenges in the… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
2007
2007
Accelerated Preclinical Testing Using Transplanted Tumors from Genetically Engineered Mouse Breast Cancer Models
Purpose: The use of genetically engineered mouse (GEM) models for preclinical testing of anticancer therapies is hampered by… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 4
  • figure 5
Is this relevant?
Review
2006
Review
2006
Model organisms: The mighty mouse: genetically engineered mouse models in cancer drug development
Deficiencies in the standard preclinical methods for evaluating potential anticancer drugs,such as xenograft mouse models, have… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE