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Genetically Engineered Mouse

Known as: GEM 
A mouse that has been genetically modified by introducing new genetic characteristics to it. It often involves the isolation, manipulation and… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Overview of Genetically Engineered Mouse Models of Prostate Cancer and Their Applications in Drug Discovery
Prostate cancer (PCa) is the most common malignant visceral neoplasm in males in Western countries. Despite progress made in the… 
2015
2015
Facilitation of endoglin‐targeting cancer therapy by development/utilization of a novel genetically engineered mouse model expressing humanized endoglin (CD105)
Endoglin (ENG) is a TGF‐β coreceptor and essential for vascular development and angiogenesis. A chimeric antihuman ENG (hENG… 
2015
2015
TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis.
Lung carcinogenesis is a multistep process in which normal lung epithelial cells are converted to cancer cells through the… 
Review
2015
Review
2015
Modeling cancer using genetically engineered mice.
Genetically engineered mouse (GEM) models have proven to be a powerful tool to study tumorigenesis. The mouse is the preferred… 
Review
2013
Review
2013
Accelerating cancer modeling with RNAi and nongermline genetically engineered mouse models.
For more than two decades, genetically engineered mouse models have been key to our mechanistic understanding of tumorigenesis… 
Review
2010
Review
2010
A Wnt-ow of opportunity: targeting the Wnt/beta-catenin pathway in breast cancer.
Aberrant activation of the Wnt/beta-catenin signaling pathway is a hallmark of many tumors, including breast cancer. In the… 
2009
2009
A quantitative volumetric micro-computed tomography method to analyze lung tumors in genetically engineered mouse models.
Two genetically engineered, conditional mouse models of lung tumor formation, K-ras(LSL-G12D) and K-ras(LSL-G12D)/p53(LSL-R270H… 
Review
2008
Review
2008
K-Ras-driven pancreatic cancer mouse model for anticancer inhibitor analyses.
2008
2008
Dynamic Small-Animal PET Imaging of Tumor Proliferation with 3′-Deoxy-3′-18F-Fluorothymidine in a Genetically Engineered Mouse Model of High-Grade Gliomas
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT), a partially metabolized thymidine analog, has been used in preclinical and clinical… 
2004
2004
Progression of Pregnancy-Dependent Mouse Mammary Tumors after Long Dormancy Periods. Involvement of Wnt Pathway Activation
Mouse mammary tumor virus (LA) induces pregnancy-dependent mammary tumors that progress toward autonomy. Here we show that in… 
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