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Genetically Engineered Mouse

Known as: GEM 
A mouse that has been genetically modified by introducing new genetic characteristics to it. It often involves the isolation, manipulation and… 
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Prostate cancer (PCa) is the most common malignant visceral neoplasm in males in Western countries. Despite progress made in the… 
2015
2015
Endoglin (ENG) is a TGF‐β coreceptor and essential for vascular development and angiogenesis. A chimeric antihuman ENG (hENG… 
2015
2015
Lung carcinogenesis is a multistep process in which normal lung epithelial cells are converted to cancer cells through the… 
Review
2015
Review
2015
Genetically engineered mouse (GEM) models have proven to be a powerful tool to study tumorigenesis. The mouse is the preferred… 
Review
2013
Review
2013
For more than two decades, genetically engineered mouse models have been key to our mechanistic understanding of tumorigenesis… 
Review
2010
Review
2010
Aberrant activation of the Wnt/beta-catenin signaling pathway is a hallmark of many tumors, including breast cancer. In the… 
2009
2009
Two genetically engineered, conditional mouse models of lung tumor formation, K-ras(LSL-G12D) and K-ras(LSL-G12D)/p53(LSL-R270H… 
2008
2008
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT), a partially metabolized thymidine analog, has been used in preclinical and clinical… 
2004
2004
Mouse mammary tumor virus (LA) induces pregnancy-dependent mammary tumors that progress toward autonomy. Here we show that in…