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Genetically Engineered Mouse

Known as: GEM 
A mouse that has been genetically modified by introducing new genetic characteristics to it. It often involves the isolation, manipulation and… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as… Expand
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Highly Cited
2016
Highly Cited
2016
Significance Knowledge of oncogenic alterations that drive lung adenocarcinoma formation has enabled the development of… Expand
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Review
2015
Review
2015
High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths, and overall survival has not changed… Expand
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Highly Cited
2013
Highly Cited
2013
Pancreatic cancer (PC) remains one of the most lethal human malignancies with poor prognosis. Despite all advances in preclinical… Expand
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Highly Cited
2011
Highly Cited
2011
Purpose To examine the in vitro and in vivo efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type… Expand
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Highly Cited
2011
Highly Cited
2011
The properties of breast cancer susceptibility protein required for tumor suppression have been explored. Germline mutations of… Expand
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Highly Cited
2010
Highly Cited
2010
Most genetically engineered mouse (GEM) models for colon cancer are based on tissuewide or germline gene modification, resulting… Expand
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Highly Cited
2008
Highly Cited
2008
Background The complexity and heterogeneity of the human plasma proteome have presented significant challenges in the… Expand
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2007
2007
Purpose: The use of genetically engineered mouse (GEM) models for preclinical testing of anticancer therapies is hampered by… Expand
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Review
2006
Review
2006
Deficiencies in the standard preclinical methods for evaluating potential anticancer drugs,such as xenograft mouse models, have… Expand
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