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Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer
Pancreatic cancer is the most lethal of all solid tumors partially because of its chemoresistance. Although gemcitabine is widely used as a first selected agent for the treatment of this disease… Expand
Electroporation-mediated gene transfer that targets glomeruli.
- M. Tsujie, Y. Isaka, H. Nakamura, E. Imai, M. Hori
- Biology, Medicine
- Journal of the American Society of Nephrology…
- 1 May 2001
Electroporation has been applied to introducing DNA into several organs; however, gene expression was localized around the injected area. Examined was the efficiency of intrarenal injection of DNA… Expand
Gene transfer targeting interstitial fibroblasts by the artificial viral envelope-type hemagglutinating virus of Japan liposome method.
BACKGROUND Tubulointerstitial inflammation and fibrosis are commonly associated with most human glomerular diseases. The degree of tubulointerstitial damage, rather than the glomerular injury, could… Expand
Expression of Tumor Suppressor Gene p16INK4 Products in Primary Gastric Cancer
Recent studies have shown that the cyclin-dependent kinase (CDK) inhibitor p27Kip1 represents an indicator for patients’ outcome in several human malignancies including gastric cancer. However, the… Expand
Prognostic impact of preoperative NLR and CA19-9 in pancreatic cancer.
- T. Asaoka, A. Miyamoto, +10 authors S. Nakamori
- Pancreatology : official journal of the…
- 1 May 2016
BACKGROUND Recently, several preoperative proinflammatory markers and nutritional factors such as neutrophil-to-lymphocyte ratio (NLR) and prognostic nutrition index (PNI) have been reported as… Expand
Significance of surgical treatment of liver metastases from gastric cancer.
BACKGROUND/AIM The optimal treatment of liver metastases from gastric cancer (LMGC) remains uncertain. We retrospectively compared surgical treatment with chemotherapy alone and identified prognostic… Expand
Molecular features of non-B, non-C hepatocellular carcinoma: a PCR-array gene expression profiling study.
BACKGROUND/AIMS Hepatocellular carcinoma (HCC) usually develops following chronic liver inflammation caused by hepatitis C or B virus. Through expression profiling in a rare type of HCC, for which… Expand
Suppression of pancreatic cancer cell invasion by a cyclooxygenase-2-specific inhibitor
Pancreatic cancer is characterized by invasive and metastatic potential. In this study, effects of the COX-2 inhibitor JTE-522 on cell viability, invasion, and invasion-related cellular properties… Expand
Prolonged transgene expression in glomeruli using an EBV replicon vector system combined with HVJ liposomes.
- M. Tsujie, Y. Isaka, H. Nakamura, Y. Kaneda, E. Imai, M. Hori
- Medicine, Biology
- Kidney international
- 1 April 2001
BACKGROUND Various gene transfer vectors as well as delivery systems have been developed; however, many problems remain to be solved. We already achieved a technique to introduce genes into… Expand
Risk factors of pancreatic fistula after pancreaticoduodenectomy - patients with low drain amylase level on postoperative day 1 are safe from developing pancreatic fistula.
BACKGROUND/AIMS Based on the criteria of International Study Group on Pancreatic Fistula (ISGPF), the risk factors for grade B/C pancreatic fistula (PF) after pancreaticoduodenectomy (PD) were… Expand