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Genetic Hotspot

Known as: Hotspot 
A genetic sequence at which mutations occur with an unusually high frequency.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Social–ecological hotspots mapping : A spatial approach for identifying coupled social–ecological space
Highly Cited
2008
Highly Cited
2008
The Impact of Recombination on Nucleotide Substitutions in the Human Genome
Unraveling the evolutionary forces responsible for variations of neutral substitution patterns among taxa or along genomes is a… 
Highly Cited
2007
Highly Cited
2007
Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward
Cannabinoid drugs such as Δ9-THC are euphoric and rewarding, and also stimulate food intake in humans and animals. Little is… 
Highly Cited
2003
Highly Cited
2003
The Emperor Seamounts: Southward Motion of the Hawaiian Hotspot Plume in Earth's Mantle
The Hawaiian-Emperor hotspot track has a prominent bend, which has served as the basis for the theory that the Hawaiian hotspot… 
Highly Cited
2002
Highly Cited
2002
Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia.
Activation of the RAS/RAF/extracellular signal-regulated kinase-mitogen-activated protein kinase/extracellular signal-regulated… 
Highly Cited
2001
Highly Cited
2001
Seismic structure and origin of hotspots and mantle plumes
Highly Cited
2000
Highly Cited
2000
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".
Although APC mutations occur at a high frequency in colorectal cancers, few studies have performed a comprehensive analysis by… 
Highly Cited
1998
Highly Cited
1998
Advection of plumes in mantle flow: implications for hotspot motion, mantle viscosity and plume distribution
Summary Because of their slow relative motion, hotspots, mainly in the Pacific, are often used as a reference frame for… 
Highly Cited
1992
Highly Cited
1992
Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis.
Highly Cited
1991
Highly Cited
1991
p53 mutation in hepatocellular carcinoma after aflatoxin exposure
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