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Genetic Hotspot

Known as: Hotspot 
A genetic sequence at which mutations occur with an unusually high frequency.
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
iRSpot-Pse6NC: Identifying recombination spots in Saccharomyces cerevisiae by incorporating hexamer composition into general PseKNC
Meiotic recombination caused by meiotic double-strand DNA breaks. In some regions the frequency of DNA recombination is… 
Highly Cited
2009
Highly Cited
2009
Label-free dual sensing of DNA molecules using GaN nanowires.
We demonstrate a rationale for using GaN nanowires (GaNNWs) in label-free DNA-sensing using dual routes of electrochemical… 
Review
2008
Review
2008
A hotspot for cold crenarchaeota in the neuston of high mountain lakes.
We have surveyed the first 1 m of 10 oligotrophic high mountain lakes in the Central Pyrenees (Spain) for both abundance and… 
Highly Cited
2005
Highly Cited
2005
A mutation hotspot at the p14ARF splice site
Germline mutations of CDKN2A that affect the p16INK4a transcript have been identified in numerous melanoma pedigrees worldwide… 
Highly Cited
2002
Highly Cited
2002
A 160-bp palindrome is a Rad50.Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe.
Palindromic sequences can form hairpin and cruciform structures that pose a threat to genome integrity. We found that a 160-bp… 
Highly Cited
2000
Highly Cited
2000
The reductive hotspot hypothesis: an update.
The mitochondrial free radical theory of aging is seriously challenged by the finding that mutant mtDNA never becomes abundant in… 
Highly Cited
1999
Highly Cited
1999
Townes‐Brocks syndrome: Detection of a SALL1 mutation hot spot and evidence for a position effect in one patient
Townes‐Brocks syndrome (TBS) is an autosomal dominant developmental disorder characterized by anal and thumb malformations and by… 
Highly Cited
1997
Highly Cited
1997
Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen
We examined the full-length hepatitis B virus (HBV) envelope (surface antigen or HBV small surface antigen [HBsAg]) sequences of… 
Highly Cited
1990
Highly Cited
1990
Calcium hotspots caused by L-channel clustering promote morphological changes in neuronal growth cones
THE increase in intracellular Ca2+concentration ([Ca2+]i) that follows electrical activity in excitable cells influences various… 
Highly Cited
1990
Highly Cited
1990
Lekking in topi: a consequence of satellite behaviour by small males at hotspots
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