Tonically active GABAA receptors: modulating gain and maintaining the tone
Synaptic connections between layer 4 spiny neurone‐ layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column
The results suggest that each connected L4 spiny neurone produces a weak but reliable EPSP in the pyramidal cell, implying that transmission of signals to layer 2/3 is likely to have a high threshold requiring simultaneous activation of many L4 neurons, and postsynaptic glutamate receptors act as a gate for the lateral spread of excitation in layer 1/3.
Modulation of Glutamate Mobility Reveals the Mechanism Underlying Slow-Rising AMPAR EPSCs and the Diffusion Coefficient in the Synaptic Cleft
Unveiling synaptic plasticity: a new graphical and analytical approach
Locus of frequency‐dependent depression identified with multiple‐probability fluctuation analysis at rat climbing fibre‐Purkinje cell synapses
The large number of functional release sites, relatively large quantal size, and unusual dynamics of transmitter release at the CF synapse appear specialized to ensure highly reliable olivocerebellar transmission at low frequencies but to limit transmission at higher frequencies.
- R. Silver
- Biology, Computer ScienceNature Reviews Neuroscience
This work presents a tool kit of nonlinear mechanisms that confers considerable computational power on both morphologically simple and more complex neurons, enabling them to perform a range of arithmetic operations on signals encoded in a variety of different ways.
Estimation of nonuniform quantal parameters with multiple-probability fluctuation analysis: theory, application and limitations
- R. Silver
- BiologyJournal of Neuroscience Methods
- 15 December 2003
Non‐NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites.
The results suggest that release of a packet of transmitter from a single release site does not saturate postsynaptic non‐NMDA receptors at cerebellar mossy fibre‐granule cell synapses, but at multi‐site synapses transmitter released from neighbouring sites can overlap, changing the transmitter concentration profile in the synaptic cleft.
Fast vesicle reloading and a large pool sustain high bandwidth transmission at a central synapse
The results establish that sustained vesicular release at high rates is not restricted to graded ribbon-type synapses and that mossy fibres are well suited for transmitting broad-bandwidth rate-coded information to the input layer of the cerebellar cortex.