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Synaptic connections between layer 4 spiny neurone‐ layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column
Whole‐cell voltage recordings were obtained from 64 synaptically coupled excitatory layer 4 (L4) spiny neurones and L2/3 pyramidal cells in acute slices of the somatosensory cortex (‘barrel’ cortex)Expand
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Locus of frequency‐dependent depression identified with multiple‐probability fluctuation analysis at rat climbing fibre‐Purkinje cell synapses
1 EPSCs were recorded under whole‐cell voltage clamp at room temperature from Purkinje cells in slices of cerebellum from 12‐ to 14‐day‐old rats. EPSCs from individual climbing fibre (CF) inputs wereExpand
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Non‐NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites.
1. Excitatory postsynaptic currents (EPSCs) were recorded under whole‐cell voltage clamp from granule cells in slices of rat cerebellum. EPSCs from individual mossy fibre inputs were identified byExpand
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Estimation of nonuniform quantal parameters with multiple-probability fluctuation analysis: theory, application and limitations
  • R. Silver
  • Medicine, Computer Science
  • Journal of Neuroscience Methods
  • 15 December 2003
Synapses are a key determinant of information processing in the central nervous system. Investigation of the mechanisms underlying synaptic transmission at central synapses is complicated by theExpand
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Fast vesicle reloading and a large pool sustain high bandwidth transmission at a central synapse
What limits the rate at which sensory information can be transmitted across synaptic connections in the brain? High-frequency signalling is restricted to brief bursts at many central excitatoryExpand
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Neuronal arithmetic
  • R. Silver
  • Medicine
  • Nature Reviews Neuroscience
  • 2010
The vast computational power of the brain has traditionally been viewed as arising from the complex connectivity of neural networks, in which an individual neuron acts as a simple linear summationExpand
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High-Probability Uniquantal Transmission at Excitatory Synapses in Barrel Cortex
The number of vesicles released at excitatory synapses and the number of release sites per synaptic connection are key determinants of information processing in the cortex, yet they remain uncertain.Expand
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Deactivation and desensitization of non‐NMDA receptors in patches and the time course of EPSCs in rat cerebellar granule cells.
1. Spontaneous and evoked non‐NMDA receptor‐mediated EPSCs were recorded from cerebellar granule cells in slices at approximately 24 and approximately 34 degrees C. The EPSC decay was fitted with theExpand
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The Contribution of Single Synapses to Sensory Representation in Vivo
The extent to which synaptic activity can signal a sensory stimulus limits the information available to a neuron. We determined the contribution of individual synapses to sensory representation byExpand
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Rapid Desynchronization of an Electrically Coupled Interneuron Network with Sparse Excitatory Synaptic Input
Summary Electrical synapses between interneurons contribute to synchronized firing and network oscillations in the brain. However, little is known about how such networks respond to excitatoryExpand
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