R. Silver

Publications71
h-index32
Citations5,419
Highly Influential Citations550
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Tonically active GABAA receptors: modulating gain and maintaining the tone
TLDR
Tonic GABAA-receptor-mediated signalling occurs in different brain regions, shows cell-type-specific differences in magnitude and pharmacology, and changes during brain development, and provides a potentially important new window onto neuronal information processing and pathological states such as epilepsy. Expand
Modulation of Glutamate Mobility Reveals the Mechanism Underlying Slow-Rising AMPAR EPSCs and the Diffusion Coefficient in the Synaptic Cleft
TLDR
The mechanism underlying slow-rising EPSCs and the diffusion coefficient of glutamate in the synaptic cleft (Dglut) at cerebellar mossy fiber-granule cell synapses is investigated using a combination of diffusion modeling and patch-clamp recording and results suggest that under control conditions Dglut is approximately 3-fold lower than in free solution. Expand
Locus of frequency‐dependent depression identified with multiple‐probability fluctuation analysis at rat climbing fibre‐Purkinje cell synapses
TLDR
The large number of functional release sites, relatively large quantal size, and unusual dynamics of transmitter release at the CF synapse appear specialized to ensure highly reliable olivocerebellar transmission at low frequencies but to limit transmission at higher frequencies. Expand
Unveiling synaptic plasticity: a new graphical and analytical approach
TLDR
A new approach is described that, in its simplest form, can identify the site of expression by direct graphical means and can quantify functional synaptic properties and determine which of these properties is altered following a modulation of synaptic strength. Expand
Non‐NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites.
TLDR
The results suggest that release of a packet of transmitter from a single release site does not saturate postsynaptic non‐NMDA receptors at cerebellar mossy fibre‐granule cell synapses, but at multi‐site synapses transmitter released from neighbouring sites can overlap, changing the transmitter concentration profile in the synaptic cleft. Expand
Estimation of nonuniform quantal parameters with multiple-probability fluctuation analysis: theory, application and limitations
  • R. Silver
  • Medicine, Computer Science
  • Journal of Neuroscience Methods
  • 15 December 2003
TLDR
The theoretical basis and the underlying assumptions of MPFA are described, illustrating how a simplified multinomial model can be used to estimate mean quantal parameters at synapses where quantal size and release probability are nonuniform. Expand
Neuronal arithmetic
  • R. Silver
  • Medicine
  • Nature Reviews Neuroscience
  • 2010
TLDR
This work presents a tool kit of nonlinear mechanisms that confers considerable computational power on both morphologically simple and more complex neurons, enabling them to perform a range of arithmetic operations on signals encoded in a variety of different ways. Expand
Fast vesicle reloading and a large pool sustain high bandwidth transmission at a central synapse
TLDR
The results establish that sustained vesicular release at high rates is not restricted to graded ribbon-type synapses and that mossy fibres are well suited for transmitting broad-bandwidth rate-coded information to the input layer of the cerebellar cortex. Expand
Spillover of Glutamate onto Synaptic AMPA Receptors Enhances Fast Transmission at a Cerebellar Synapse
TLDR
It is proposed that spillover of glutamate improves transmission efficacy by both increasing the amplitude and duration of the EPSP and reducing fluctuations arising from the probabilistic nature of transmitter release. Expand
The Contribution of Single Synapses to Sensory Representation in Vivo
TLDR
V Vestibular-sensitive synapses faithfully reported direction and velocity, rather than position or acceleration of whole-body motion, via bidirectional modulation of EPSC frequency, indicating that highly accurate stimulus representation can be achieved by small networks and even within single neurons. Expand
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