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Genes, nef

Known as: HIV 3' orf Genes, HIV-3'-orf Gene, nef gene 
DNA sequences that form the coding region for a protein that down-regulates the expression of human immunodeficiency virus (HIV). nef is short for… 
National Institutes of Health

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Broader (1)

Genes, Regulator
aspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2007
Highly Cited
2007
Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection
ABSTRACT A human immunodeficiency virus (HIV)-preventive vaccine will likely need to induce broad immunity that can recognize… 
2007
2007
Comparative evaluation of oral and intranasal priming with replication-competent adenovirus 5 host range mutant (Ad5hr)-simian immunodeficiency virus (SIV) recombinant vaccines on immunogenicity and…
2004
2004
Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase.
Highly Cited
1999
Highly Cited
1999
Sequence Variations in Human Immunodeficiency Virus Type 1 Nef Are Associated with Different Stages of Disease
ABSTRACT nef alleles derived from a large number of individuals infected with human immunodeficiency virus type 1 (HIV-1) were… 
Highly Cited
1999
Highly Cited
1999
Human Immunodeficiency Virus Type 1 Nef Protein Sensitizes CD4+ T Lymphoid Cells to Apoptosis via Functional Upregulation of the CD95/CD95 Ligand Pathway
Many viruses have evolved genes encoding proteins that regulate cell death by apoptosis. The human immunodeficiency virus type 1… 
1999
1999
Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Nef Proteins Show Distinct Patterns and Mechanisms of Src Kinase Activation
ABSTRACT The nef gene from human and simian immunodeficiency viruses (HIV and SIV) regulates cell function and viral replication… 
Highly Cited
1999
Highly Cited
1999
Induction of AIDS in Rhesus Monkeys by a Recombinant Simian Immunodeficiency Virus Expressing nef of Human Immunodeficiency Virus Type 1
ABSTRACT A nef gene is present in all primate lentiviruses, including human immunodeficiency virus type 1 (HIV-1) and simian… 
Highly Cited
1995
Highly Cited
1995
Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression
We have studied the sequence and function of the human immunodeficiency virus type 1 (HIV-1) nef genes from nine patients with… 
Highly Cited
1993
Highly Cited
1993
The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4
The nef gene product of human immunodeficiency virus type 1 has been shown to induce CD4 downregulation from the surface of human… 
Highly Cited
1993
Highly Cited
1993
Identification of cellular proteins that bind to the human immunodeficiency virus type 1 nef gene product in vitro: a role for myristylation.
The human immunodeficiency virus (HIV) type 1 nef gene product was expressed as an N-terminal fusion protein with glutathione-S… 
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