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Gastrointestinal Lipase Inhibitor

Any substance that inhibits gastrointestinal lipase, an enzyme that is involved in the absorption of dietary lipids. Inhibition of gastrointestinal… 
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Orlistat is an oral inhibitor of gastrointestinal lipase used for weight reduction in obese patients. Although most adverse drug… 
Highly Cited
2004
Highly Cited
2004
The effect of orlistat, a nonabsorbed inhibitor of gastric and pancreatic lipases, was examined in patients with primary… 
Highly Cited
2004
Highly Cited
2004
BACKGROUND Unabsorbed fat and bile acids may react with calcium in the intestinal lumen, limiting the amount of free calcium… 
Highly Cited
2002
Highly Cited
2002
OBJECTIVE The purpose of this study was to assess the effect of orlistat, a gastrointestinal lipase inhibitor, on body weight… 
Highly Cited
2001
Highly Cited
2001
OBJECTIVES: This placebo-controlled open study was designed to test the hypothesis that most of the gastrointestinal (GI) side… 
Review
2000
Review
2000
OBJECTIVE: To assess the efficacy and tolerability of orlistat (Xenical®) in producing and maintaining weight loss over a 12… 
Highly Cited
1999
Highly Cited
1999
CONTEXT Orlistat, a gastrointestinal lipase inhibitor that reduces dietary fat absorption by approximately 30%, may promote… 
Highly Cited
1999
Highly Cited
1999
BACKGROUND Long-term maintenance of weight loss remains a therapeutic challenge in obesity treatment. OBJECTIVE This… 
1999
1999
Orlistat, a gastrointestinal lipase inhibitor, decreases fat absorption and thus it reduces caloric intake. The objectives of… 
Review
1992
Review
1992
Excessive intake of dietary fat contributes to the development and maintenance of both obesity and hyperlipidemia. Inhibition of…