D. Hartmann

Publications50
h-index21
Citations1,618
Highly Influential Citations41
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Plasma kinetics of zeaxanthin and 3'-dehydro-lutein after multiple oral doses of synthetic zeaxanthin.
BACKGROUND Zeaxanthin is hypothesized to reduce the risk of age-related macular degeneration; however, kinetic information is limited. OBJECTIVES The objective was to investigate the plasma… Expand
  • 65
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Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitor
BACKGROUND AND AIMS To investigate the importance of lipase on gastric functions, we studied the effects of orlistat, a potent and specific inhibitor of lipase, on postprandial gastric acidity and… Expand
  • 66
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Role of lipase in the regulation of upper gastrointestinal function in humans.
The role of lipase in the regulation of upper gastrointestinal function is poorly understood. We studied the effect of orlistat, a new, potent, and highly specific lipase inhibitor, on gastric… Expand
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On the requirements of ascorbic acid in man: steady-state turnover and body pool in smokers.
The time course of radioactivity in plasma and urine after oral administration of a single dose of (1-14 C) ascorbic acid has been followed in healthy male volunteers smoking more than 20 cigarettes… Expand
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On the absorption of ascorbic acid in man.
The daily intake of ascorbic acid with the diet was strongly restricted in seven healthy non-smoking males and 90 to 180 mg of ascorbic acid were orally supplemented. After an equilibration period of… Expand
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Steady-state turnover and body pool of ascorbic acid in man.
The time course of radioactivity in plasma and urine after oral administration of a single dose of (1-14C)ascorbic acid has been followed in healthy nonsmoking male volunteers. The investigation was… Expand
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Pharmacokinetics of Digoxin and Main Metabolites/Derivatives in Healthy Humans
Three healthy, young male volunteers received doses of 0.6 and 1.2 mg of specifically labelled [3H]digoxin each by intravenous (i.v.) bolus injection and oral (p.o.) administration in accordance with… Expand
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Absorption of large, single, oral intakes of ascorbic acid.
A male non-smoking volunteer increased his daily intake of ascorbic acid continuously by ingesting in a single, oral dose 1, 2, 3, 4 and 5 g crystalline ascorbic acid. The dose was always kept… Expand
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The pH Dependency of the Binding of Drugs to Plasma Proteins in Man
An analysis of pH-induced changes of drug binding may contribute to the understanding of the mechanisms involved and the clinical relevance. A literature search was performed, and acceptance criteria… Expand
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Degree of in vivo inhibition of human gastric and pancreatic lipases by Orlistat (Tetrahydrolipstatin, THL) in the stomach and small intestine.
BACKGROUND AND AIMS Orlistat, a lipase inhibitor, strongly inhibits the activities of all gastric/pancreatic lipases except pancreatic phospholipase A(2)in vitro. In clinical use, for obesity… Expand
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