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GW8510

National Institutes of Health

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2019
2019
Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis
We present a system-level analysis of proteome, phosphoproteome, and chromatin state of precursors of muscle cells (myoblasts… 
2016
2016
Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent.
We carried out a gene expression-based in silico screen in order to identify small molecules with gene-expression profiles that… 
2016
2016
A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β
Background New therapeutics are needed for neglected tropical diseases including Human African trypanosomiasis (HAT), a… 
2014
2014
Quantitative-Proteomic Comparison of Alpha and Beta Cells to Uncover Novel Targets for Lineage Reprogramming
Type-1 diabetes (T1D) is an autoimmune disease in which insulin-secreting pancreatic beta cells are destroyed by the immune… 
2006
2006
Downregulation of XIAP and induction of apoptosis by the synthetic cyclin-dependent kinase inhibitor GW8510 in non-small cell lung cancer cells
Small-molecule inhibitors of cyclin-dependent kinases (CDKs) are known to induce cell cycle arrest and apoptosis in certain… 
2006
2006
CDK inhibitor targets—A hit or miss proposition?: Cyclin-dependent kinase inhibitors kill tumor cells by downregulation of antiapoptotic proteins
Commentary to: Downregulation of XIAP and Induction of Apoptosis by the Synthetic Cyclin-Dependent Kinase Inhibitor GW8510 in Non… 
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