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GW2974
Known as:
GW282974A
, GW2974A
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Quinazolines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance.
K. Sodani
,
A. Tiwari
,
+6 authors
Zhe-Sheng Chen
Biochemical Pharmacology
2012
Corpus ID: 24777472
2012
2012
Differential effects of low‐ and high‐dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion
Lulu Wang
,
Qian Liu
,
+6 authors
Stephen T C Wong
Journal of Neuroscience Research
2012
Corpus ID: 28298717
Aberrant expression of epidermal growth factor receptor (EGFR; ErbB1) and HER2 (ErbB2) tyrosine kinases frequently occurs in…
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2011
2011
Truncated ErbB2 Expressed in Tumor Cell Nuclei Contributes to Acquired Therapeutic Resistance to ErbB2 Kinase Inhibitors
W. Xia
,
Zuguo Liu
,
+14 authors
N. Spector
Molecular Cancer Therapeutics
2011
Corpus ID: 19087716
ErbB2 tyrosine kinase inhibitors (TKI) block tyrosine autophosphorylation and activation of the full-length transmembrane ErbB2…
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2010
2010
Effects of the ErbB1/ErbB2 kinase inhibitor GW2974 on androgen-independent prostate cancer PC-3 cell line growth and NSE, chromogranin A and osteopontin content.
D. Terracciano
,
C. Mazzarella
,
+7 authors
V. Macchia
Oncology Report
2010
Corpus ID: 18535736
Prostate cancer is one of the most frequently diagnosed cancer in men. Treatment by radical prostatectomy, radiotherapy and anti…
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2009
2009
Endurance exercise training preserves cardiac function in rats receiving doxorubicin and the HER-2 inhibitor GW2974
K. Wonders
,
D. Hydock
,
S. Greufe
,
C. Schneider
,
R. Hayward
Cancer Chemotherapy and Pharmacology
2009
Corpus ID: 22954782
PurposeTo determine if endurance exercise training performed prior to administration of the anticancer drugs DOX and GW2974 would…
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2008
2008
Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of a dual inhibitor of epidermal growth factor receptor (EGFR) and…
Zheng Sun
,
S. Sood
,
+4 authors
Xiaoxin L Chen
Oral Oncology
2008
Corpus ID: 23562534
Highly Cited
2007
Highly Cited
2007
Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells
N. Spector
,
Y. Yarden
,
+7 authors
S. Bacus
Proceedings of the National Academy of Sciences
2007
Corpus ID: 24652981
The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes, and its inhibition may…
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Highly Cited
2007
Highly Cited
2007
Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor.
L. Witters
,
A. Witkoski
,
M. Planas-Silva
,
M. Berger
,
J. Viallet
,
A. Lipton
Oncology Report
2007
Corpus ID: 37438193
The epidermal growth factor receptor (EGFR) (ErbB1) and HER-2/neu (ErbB2) are members of the ErbB family of receptor tyrosine…
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2006
2006
Receptor tyrosine kinase (RTK) inhibition is effective in chemosensitising EGFR-expressing drug resistant human ovarian cancer cell lines when used in combination with cytotoxic agents.
H. Coley
,
C. Shotton
,
Abi O Ajose-Adeogun
,
H. Modjtahedi
,
H. Thomas
Biochemical Pharmacology
2006
Corpus ID: 1777286
2005
2005
Chemopreventive and Therapeutic Efficacy of Orally Active Tyrosine Kinase Inhibitors in a Transgenic Mouse Model of Gallbladder Carcinoma
K. Kiguchi
,
L. Ruffino
,
T. Kawamoto
,
T. Ajiki
,
J. DiGiovanni
Clinical Cancer Research
2005
Corpus ID: 1245530
Biliary tract cancer (BTC) is the second most common primary hepatobiliary cancer after hepatocellular cancer. At the time of…
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