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GW2974

Known as: GW282974A, GW2974A 
National Institutes of Health

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Broader (1)

Quinazolines

Papers overview

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2012
2012
Differential effects of low‐ and high‐dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion
Aberrant expression of epidermal growth factor receptor (EGFR; ErbB1) and HER2 (ErbB2) tyrosine kinases frequently occurs in… 
2011
2011
Therapeutic Discovery Truncated ErbB 2 Expressed in Tumor Cell Nuclei Contributes to Acquired Therapeutic Resistance to ErbB 2 Kinase Inhibitors
ErbB2 tyrosine kinase inhibitors (TKI) block tyrosine autophosphorylation and activation of the full-length transmembrane ErbB2… 
2010
2010
Dual Inhibition of Both the Epidermal Growth Factor Receptor and erbB2 Effectively Inhibits the Promotion of Skin Tumors during Two-Stage Carcinogenesis
The erbB family of receptor tyrosine kinases are known to play important roles in normal epithelial development and epithelial… 
2009
2009
Synergistic Growth Inhibition with a PI3 Kinase/mTOR Inhibitor Plus Lapatinib.
The mammalian target of rapamycin, mTOR, is a member of the phosphatidylinositol 3-kinase (PI3-K) /Akt family and plays a key… 
2008
2008
Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of a dual inhibitor of epidermal growth factor receptor (EGFR) and…
2008
2008
Characterization of the Role of Breast Tumor Kinase (BRK) in Breast Cancer Cells Non-responsive to EGFR-targeted Agents
Abstract : Epidermal growth factor (EGF) receptor tyrosine kinases (erbB family), EGFR (erbB1) and HER2, are highly expressed in… 
2008
2008
Inhibitng effects of GW2974 on EGFR and proto-oncogenes in DMBA-induced hamster buccal pouch carcinogenesis model
Objective To study the inhibiting effects of GW2974, a tyrosine kinase inhibitors (TKIs), on EGFR and proto-oncogenes c-Fos and c… 
2007
2007
[Inhibiting effects of GW2974 on DMBA-induced hamster buccal pouch carcinogenesis].
OBJECTIVE To evaluate the inhibiting effects of GW2974, a tyrosine kinase inhibitors, on dimethyl-benzanthracene (DMBA)-induced… 
2006
2006
Therapeutic implications for acquired resistance and heart toxicity using targeted therapy to erbB2.
3084 Background: ErbB2 overexpression predicts for a poor prognosis in breast cancer making it an attractive therapeutic target… 
2006
2006
Synergistic inhibition of breast cancer cell lines with the combination of a dual inhibitor of EGFR/HER-2/neu and a Bcl-2 inhibitor.
13100 Background: The epidermal growth factor receptor (EGFR; ErbB1) and HER-2/neu (ErbB2), members of the ErbB family of… 
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