GW2974

Known as: GW282974A, GW2974A 
 
National Institutes of Health

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Quinazolines

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2012
2012
GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance.
The overexpression of ATP binding cassette (ABC) transporters often leads to the development of multidrug resistance (MDR) and… (More)
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2012
2012
Differential effects of low- and high-dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion.
Aberrant expression of epidermal growth factor receptor (EGFR; ErbB1) and HER2 (ErbB2) tyrosine kinases frequently occurs in… (More)
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2011
2011
Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors.
ErbB2 tyrosine kinase inhibitors (TKI) block tyrosine autophosphorylation and activation of the full-length transmembrane ErbB2… (More)
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2011
2011
Therapeutic Discovery Truncated ErbB 2 Expressed in Tumor Cell Nuclei Contributes to Acquired Therapeutic Resistance to ErbB 2 Kinase Inhibitors
ErbB2 tyrosine kinase inhibitors (TKI) block tyrosine autophosphorylation and activation of the full-length transmembrane ErbB2… (More)
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2009
2009
Endurance exercise training preserves cardiac function in rats receiving doxorubicin and the HER-2 inhibitor GW2974
To determine if endurance exercise training performed prior to administration of the anticancer drugs DOX and GW2974 would be… (More)
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2008
2008
Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of a dual inhibitor of epidermal growth factor receptor (EGFR) and…
Oral cancer is a common neoplasm worldwide with tobacco and alcohol being the major etiological factors contributing to its… (More)
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Highly Cited
2007
Highly Cited
2007
Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells.
The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes, and its inhibition may… (More)
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2007
2007
Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor.
The epidermal growth factor receptor (EGFR) (ErbB1) and HER-2/neu (ErbB2) are members of the ErbB family of receptor tyrosine… (More)
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2007
2007
[Inhibiting effects of GW2974 on DMBA-induced hamster buccal pouch carcinogenesis].
OBJECTIVE To evaluate the inhibiting effects of GW2974, a tyrosine kinase inhibitors, on dimethyl-benzanthracene (DMBA)-induced… (More)
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2005
2005
Chemopreventive and therapeutic efficacy of orally active tyrosine kinase inhibitors in a transgenic mouse model of gallbladder carcinoma.
Biliary tract cancer (BTC) is the second most common primary hepatobiliary cancer after hepatocellular cancer. At the time of… (More)
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