GTP cyclohydrolase I activity

Known as: GTP 7,8-8,9-dihydrolase activity, guanosine triphosphate cyclohydrolase activity, dihydroneopterin triphosphate synthase activity 
Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate. [EC:3.5.4.16]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2013
02419762013

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2011
2011
The underlying defects in Angelman syndrome (AS) and autism spectrum disorder (ASD) may be in part due to basic defects in… (More)
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2005
2005
Inducible nitric oxide synthase (iNOS) is a prominent component of the complex array of mediators in acute graft rejection. While… (More)
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2003
2003
Tetrahydrobiopterin (BH4) acts as an essential cofactor for the enzymatic activity of nitric oxide (NO) synthases. Biosynthesis… (More)
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1998
1998
GTP cyclohydrolase I controls the de novo pathway for the synthesis of tetrahydrobiopterin, which is the essential cofactor for… (More)
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1995
1995
GTP cyclohydrolase I activity in mononuclear blood cells from patients with juvenile parkinsonism (JP) was found to be normal… (More)
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1994
1994
GTP cyclohydrolase I catalyzes the initial and rate limiting step of the biosynthesis of tetrahydrobiopterin, the cofactor for… (More)
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1993
1993
Guanosine triphosphate (GTP) cyclohydrolase I, the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin (BH4), is… (More)
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1986
1986
In a recent publication, evidence was presented that cellular immune responses are associated with increased in vivo and in vitro… (More)
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1985
1985
An assay is described for GTP cyclohydrolase I activity in human mononuclear cells isolated from 20 ml of heparinized blood. The… (More)
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1984
1984
A 4-year-old patient is described with hyperphenylalaninemia, severe retardation in development, severe muscular hypotonia of the… (More)
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