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GTP 14564

Known as: GTP-14564, GTP14564 
National Institutes of Health

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2 relations

Broader (2)

BenzofuransPyrazoles

Papers overview

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2005
2005
Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway
17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of the molecular chaperone heat shock protein 90, results in cell… 
2004
2004
The Hsp90 Inhibitor 17-AAG and FLT3 Kinase Inhibitor GTP14564 Synergistically Inhibit MLL Fusion Gene Leukemias with FLT3 Mutations.
17-AAG, an inhibitor of the molecular chaperone Hsp90, results in apoptosis and inhibition of proliferation of certain leukemia… 
Highly Cited
2003
Highly Cited
2003
Selective Cytotoxic Mechanism of GTP-14564, a Novel Tyrosine Kinase Inhibitor in Leukemia Cells Expressing a Constitutively Active Fms-like Tyrosine Kinase 3 (FLT3)*
The receptor tyrosine kinase FLT3 is constitutively activated by an internal tandem duplication (ITD) mutation within the… 
2003
2003
Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active FLT3 Running title: Essential roles of STAT5 in the mutant FLT3…
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