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GT 2331

Known as: GT-2331 
 
National Institutes of Health

Papers overview

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2007
2007
An investigation of the absolute configuration of the potent histamine H3 receptor antagonist GT-2331 using vibrational circular dichroism.
GT-2331 [(+)-1] is one of the most potent members of a class of chiral drug substances used to regulate the synthesis and release… Expand
2006
2006
Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor.
Histamine H(3) receptor antagonists are potential therapeutic agents for cognitive dysfunction, epilepsy, hypersomnia and obesity… Expand
2005
2005
G Protein-Dependent Pharmacology of Histamine H3 Receptor Ligands: Evidence for Heterogeneous Active State Receptor Conformations
Previously reported pharmacological studies using the imidazole-containing histamine H3 receptor ligands GT-2331 (Cipralisant… Expand
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2004
2004
An efficient multigram synthesis of the potent histamine H3 antagonist GT-2331 and the reassessment of the absolute configuration.
GT-2331 is a potent histamine H(3) antagonist which has entered clinical trials. Efficient multigram syntheses of this compound… Expand
Highly Cited
2002
Highly Cited
2002
Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup
Histamine H(3) receptor antagonists have been proposed as potentially useful therapeutic agents for the treatment of several… Expand
2002
2002
Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model
The selective H(3) receptor agonist (R)-alpha-methylhistamine [(R)-alpha-MeHA] stimulates drinking in the adult rat. In the… Expand
2000
2000
Histamine H3 receptor antagonists
The histamine H3 receptor provides a negative feedback mechanism for the release and synthesis of histamine. On non-histaminergic… Expand
1999
1999
Development of trans-2-[1H-imidazol-4-yl] cyclopropane derivatives as new high-affinity histamine H3 receptor ligands.
Previously, a novel series of 1H-4-substituted imidazole compounds were described as potent and selective histamine (HA) H3… Expand
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1998
1998
High antagonist potency of GT-2227 and GT-2331, new histamine H3 receptor antagonists, in two functional models.
GT-2227 (4-(6-cyclohexylhex-cis-3-enyl)imidazole) and GT-2331 ((1R,2R)-4-(2-(5,5-dimethylhex-1-ynyl)cyclopropyl)imidazole) were… Expand
1998
1998
Pharmacological characterization of GT-2331, a new CNS-penetrating high affinity histamine H3 receptor antagonist
 
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