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Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury
- W. Schwaeble, N. Lynch, C. Stover
- BiologyProceedings of the National Academy of Sciences
- 18 April 2011
A unique model of total lectin pathway deficiency, a mouse strain lacking mannan-binding lectin-associated serine protease-2, and the therapeutic effects of MASP-2 inhibition suggest the utility of anti–MASP-1/3 antibody therapy in reperfusion injury and other Lectin pathway-mediated disorders.
Mirtazapine treatment after conditioning with methamphetamine alters subsequent expression of place preference.
Therapeutic potential of histamine H3 receptor agonists and antagonists.
Quantitative analysis of transcranial and intraparenchymal light penetration in human cadaver brain tissue
- C. Tedford, Scott Delapp, S. Jacques, J. Anders
- Medicine, BiologyLasers in surgery and medicine
- 1 April 2015
This study investigated the light penetration gradients in the human cadaver brain using a Transcranial Laser System with a 30 mm diameter beam of 808 nm wavelength light and the wavelength‐dependence of light scatter and absorbance in intraparenchymal brain tissue using 660, 808, and 940nm wavelengths was investigated.
Nullifying drug-induced sensitization: behavioral and electrophysiological evaluations of dopaminergic and serotonergic ligands in methamphetamine-sensitized rats.
Low‐level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons in vitro
- Ying-ying Huang, K. Nagata, C. Tedford, Thomas J. McCarthy, M. Hamblin
- Biology, ChemistryJournal of biophotonics
- 27 December 2012
Although LLLT increases ROS in normal neurons, it reduces ROS in oxidatively‐stressed neurons and in both cases MMP is increased, which may explain how L LLT can reduce clinical oxidative stress in various lesions while increasing ROS in cells in vitro.
High antagonist potency of GT-2227 and GT-2331, new histamine H3 receptor antagonists, in two functional models.
The regulation of one-carbon oxidation in the rat by nitrous oxide and methionine.
Pulsed Light Irradiation Improves Behavioral Outcome in a Rat Model of Chronic Mild Stress
- Xingjia Wu, S. Alberico, H. Moges, L. De Taboada, C. Tedford, J. Anders
- Psychology, BiologyLasers in surgery and medicine
- 1 March 2012
The results support the hypothesis that TLT could be used to treat other central nervous system conditions, such as depression, after it was studied in a rat model of chronic mild stress.
Low‐level laser therapy (810 nm) protects primary cortical neurons against excitotoxicity in vitro
Although the prevention of cell death was modest but significant, LLLT gave highly significant benefits in increasing ATP, raising mitochondrial membrane potential, reducing intracellular calcium concentrations, reducing oxidative stress and reducing nitric oxide.