GSK525762A

Known as: IBET compound, GSK 525762A, I-BET762 
A small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic… Expand
National Institutes of Health

Papers overview

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2019
2019
OBJECTIVE Hepatocellular carcinoma (HCC), mostly developed in fibrotic/cirrhotic liver, exhibits relatively low responsiveness to… Expand
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2018
2018
Recently, several kinase inhibitors were found to also inhibit bromodomains, providing a new strategy for the discovery of… Expand
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2018
2018
BET inhibitors exhibit broad activity in cancer models, making predictive biomarkers challenging to define. Here we investigate… Expand
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2016
2016
  • Peter J. O'Dwyer, Sarina Anne Piha-Paul, +13 authors Christine L. Hann
  • 2016
Background: GSK525762 is a potent, selective pan-BET inhibitor that abrogates binding of BET family proteins (BRD2, BRD3, BRD4… Expand
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2016
2016
Background: Bromodomains (BRDs) are domains found in a variety of proteins that recognize and bind to acetylated lysine residues… Expand
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2015
2015
Airway smooth muscle (ASM) mass is increased in asthma, and ASM cells from patients with asthma are hyperproliferative and… Expand
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2014
2014
The bromodomain and extraterminal domain (BET)-containing proteins are a class of epigenetic regulators known as “chromatin… Expand
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2013
2013
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a poorly differentiated squamous cell carcinoma that is characterized… Expand
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2013
2013
Bromodomain and extra-terminal (BET) proteins belong to a class of proteins collectively called epigenetic "readers". BET… Expand
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Highly Cited
2013
Highly Cited
2013
The bromo and extra C-terminal domain (BET) family of bromodomains are involved in binding epigenetic marks on histone proteins… Expand
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