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GSK1325756

National Institutes of Health

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PiperidinesSulfones

Papers overview

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2019
2019
Efficacy and Safety of Danirixin (GSK1325756) Co-administered With Standard-of-Care Antiviral (Oseltamivir): A Phase 2b, Global, Randomized Study of Adults Hospitalized With Influenza
Abstract Background Excessive neutrophil migration has been correlated with influenza symptom severity. Danirixin (GSK1325756), a… 
2018
2018
The COPD Pipeline XXXVII.
  • N. Gross
  • Chronic obstructive pulmonary diseases
  • 2018
  • Corpus ID: 4707345
From the GlaxoSmithKline trial of danirixin: “The inflammation associated with chronic obstructive pulmonary disease (COPD) is… 
2017
2017
Identification and characterisation of a salt form of Danirixin with reduced pharmacokinetic variability in patient populations
2017
2017
Late Breaking Abstract - Danirixin (GSK1325756) improves respiratory symptoms and health status in mild to moderate COPD – results of a 1 year first time in patient study
Background: Danirixin (DNX) is a competitive, reversible CXCR2 chemokine receptor antagonist. CXCR2 antagonists inhibit… 
2015
2015
The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756) − a selective CXCR2 antagonist − in healthy adult subjects
BackgroundExcessive neutrophil presence and activation is important in a number of acute and chronic inflammatory diseases. The… 
2014
2014
The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers
Danirixin (GSK1325756) is a small, high-affinity, selective and reversible CXCR2 antagonist in development for treatment of… 
2013
2013
Assessment of potential drug interactions by characterization of human drug metabolism pathways using non‐invasive bile sampling
Characterization of the biliary disposition of GSK1325756, using a non‐invasive bile sampling technique and spectrometric… 
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