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GSK1265744

Known as: GSK744 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Pyridones

Narrower (1)

cabotegravir

Papers overview

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Highly Cited
2017
Highly Cited
2017
Safety and tolerability of long-acting cabotegravir injections in HIV-uninfected men (ECLAIR): a multicentre, double-blind, randomised, placebo-controlled, phase 2a trial.
BACKGROUND Cabotegravir (GSK1265744) is an HIV-1 integrase strand transfer inhibitor with potent antiviral activity and a long… Expand
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2015
2015
Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection.
GSK1265744 is a new HIV integrase strand transfer inhibitor (INSTI) engineered to deliver efficient antiviral activity with a… Expand
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Highly Cited
2015
Highly Cited
2015
Cabotegravir plus rilpivirine, once a day, after induction with cabotegravir plus nucleoside reverse transcriptase inhibitors in antiretroviral-naive adults with HIV-1 infection (LATTE): a randomised…
BACKGROUND In phase 1 trials, the HIV-1 integrase strand transfer inhibitor cabotegravir (GSK1265744) was well tolerated, both… Expand
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2015
2015
The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challenge
The long-acting GSK744 HIV integrase inhibitor prevents vaginal SHIV infection in pigtail macaques. A Step-Up for PrEP Daily… Expand
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Highly Cited
2014
Highly Cited
2014
GSK1265744 pharmacokinetics in plasma and tissue after single-dose long-acting injectable administration in healthy subjects.
BACKGROUND GSK1265744 (744) is an HIV-1 integrase inhibitor in clinical development as a long-acting (LA) injectable formulation… Expand
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Highly Cited
2014
Highly Cited
2014
Pharmacokinetics, safety, and tolerability with repeat doses of GSK1265744 and rilpivirine (TMC278) long-acting nanosuspensions in healthy adults.
OBJECTIVE Pharmacokinetics, safety, and tolerability of GSK1265744 (744) and rilpivirine (RPV) (TMC278) were assessed after… Expand
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Highly Cited
2014
Highly Cited
2014
Long-Acting Integrase Inhibitor Protects Macaques from Intrarectal Simian/Human Immunodeficiency Virus
GSK1265744 (GSK744) is an integrase strand-transfer inhibitor that has been formulated as a long-acting (LA) injectable suitable… Expand
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2013
2013
Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).
We report herein the discovery of the human immunodeficiency virus type-1 (HIV-1) integrase inhibitors dolutegravir (S/GSK1349572… Expand
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Highly Cited
2013
Highly Cited
2013
Lack of pharmacokinetic interaction between rilpivirine and integrase inhibitors dolutegravir and GSK1265744.
Dolutegravir (DTG) and GSK1265744 are HIV integrase inhibitors (INIs) in clinical development. The oral formulation of… Expand
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2013
2013
Pharmacokinetics, Safety, and Monotherapy Antiviral Activity of GSK1265744, an HIV Integrase Strand Transfer Inhibitor
Abstract Background: GSK1265744 is an HIV integrase strand transfer inhibitor selected for clinical development. Objective: This… Expand
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