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GSK126

National Institutes of Health

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IndolesPyridones

Papers overview

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2020
2020
Low doses of deoxynivalenol inhibit the cell migration mediated by H3K27me3-targeted downregulation of TEM8 expression.
2020
2020
Induction of Myogenic Differentiation Improves Chemosensitivity of Chemoresistant Cells in Soft-Tissue Sarcoma Cell Lines
Rhabdomyosarcoma (RMS) and rhabdoid tumors (RT) are rare soft-tissue malignancies with the highest incidence in infants, children… 
2017
2017
PTEN Is Fundamental for Elimination of Leukemia Stem Cells Mediated by GSK126 Targeting EZH2 in Chronic Myelogenous Leukemia
Purpose: Leukemia stem cells (LSCs) are an important source of tyrosine kinase inhibitor resistance and disease relapse in… 
2017
2017
Chromatin biology: Breaking into the PRC2 cage.
New small-molecule inhibitors of the histone methyltransferase PRC2 interfere with the allosteric activation of enzymatic… 
2017
2017
Enhancing chemotherapy sensitivity by targeting PcG via the ATM/p53 pathway.
Histone modification and chromatin remodeling are important events in response to DNA damage, and Polycomb group (PcG) proteins… 
2017
2017
EZH2 suppresses the nucleotide excision repair in nasopharyngeal carcinoma by silencing XPA gene
The enhancer of zeste homolog 2 (EZH2) is involved in a number of fundamental pathological processes of cancer. However, its role… 
2016
2016
Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays.
2016
2016
[Effect of a novel EZH2 inhibitor GSK126 on prostate cancer cells].
Objective: To investigate the effect of a novel EZH2 inhibitor GSK126 on cell growth, apoptosis and migration of prostate cancer… 
2016
2016
EZH2 Inhibitor GSK126 Exhibits Osteo-Anabolic Properties in MM Bone Disease and Synergizes with Bortezomib to Inhibit MM Cell Viability
Multiple myeloma (MM) is the most frequent cancer to involve the skeleton with patients developing osteolytic bone lesions due to… 
2016
2016
EZH 2 inhibitors transcriptionally upregulate cytotoxic autophagy and cytoprotective unfolded protein response in human colorectal cancer cells
Enhancer of zeste homolog 2 (EZH2) has been emerged as novel anticancer target. Various EZH2 small-molecule inhibitors have been… 
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