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GSK 256066

Known as: GSK-256066, GSK256066 
 
National Institutes of Health

Papers overview

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2016
2016
BackgroundCD8 lymphocytes play an important role in the pathogenesis of COPD. Corticosteroids and phosphodiesterase 4 (PDE4… Expand
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2016
2016
Phosphodiesterase 4 (PDE4) inhibitors are approved for the treatment of some moderate to severe inflammatory conditions. However… Expand
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2015
2015
Glucocorticoids, also known as corticosteroids, induce effector gene transcription as a part of their anti-inflammatory… Expand
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2015
2015
This study examined the pharmacologic characterization of CHF6001 [(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4… Expand
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2015
2015
Cyclic nucleotide phosphodiesterases (PDEs) have been identified as important enzyme targets for drug development in both humans… Expand
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2015
2015
CHF6001 [(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido… Expand
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Review
2011
Review
2011
Since more than two decades anti-inflammatory effects of inhibitors of phosphodiesterase-4 have been described in numerous… Expand
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2011
2011
Oral phosphodiesterase (PDE) 4 inhibitors have demonstrated clinical efficacy in chronic obstructive pulmonary disease and asthma… Expand
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Highly Cited
2010
Highly Cited
2010
GSK256066 is a selective phosphodiesterase 4 inhibitor that can be given by inhalation, minimising the potential for side effects… Expand
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2009
2009
Crystallography driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the… Expand
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