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GSK 1363089

Known as: GSK1363089, GSK-1363089, Multitargeted Tyrosine Kinase Inhibitor GSK1363089 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

AnilidesQuinolines

Narrower (3)

EXEL 2880XL880foretinib

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells
Prostate cancer (PCa) is a metastatic malignant cancer driven by complex pathological mechanisms and characterized by poor long… 
2013
2013
F1000Prime recommendation of Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer.
2013
2013
Faculty Opinions recommendation of Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer.
2013
2013
26PD FORETINIB (GSK1363089), A MULTIKINASE INHIBITOR OF MET AND VEGFS, OVERCOMES RESISTANCE TO BEVACIZUMAB IN AN IN VIVO MODEL OF ACQUIRED BEVACIZUMAB RESISTANCE
2013
2013
F1000Prime recommendation of Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer.
2012
2012
LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling.
Smac mimetics block inhibitor of apoptosis proteins to trigger TNFα-dependent apoptosis in cancer cells. However, only a small… 
2012
2012
A Comparison of the pharmacokinetics of the anticancer MET inhibitor foretinib free base tablet formulation to bisphosphate salt capsule formulation in patients with solid tumors
SummaryPurpose This phase I, open-label, randomized, 2-part crossover study assessed the safety, pharmacokinetics and relative… 
2012
2012
Abstract LB-149: The OPCML tumor suppressor binds and negatively regulates the Axl receptor tyrosine kinase, sensitizing cells to foretinib in epithelial ovarian cancer (EOC)
OPCML (opioid binding protein/cell adhesion like molecule) is a tumour suppressor gene that is silenced almost by somatic… 
2010
2010
109 Foretinib (GSK1363089) inhibits growth of gastric cancer cell lines through blockade of inter-receptor tyrosine kinases networks
Review
2004
Review
2004
Neuropeptide mimetics for pain management
Abstract The discovery of numerous endogenous neuropeptides that participate in the formation, transmission, modulation, and… 
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