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GSK 1034702

Known as: GSK-1034702, GSK1034702 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Benzimidazoles

Papers overview

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2018
2018
Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
The realization of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (mAChR) for the treatment of… Expand
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2017
2017
Retrospective use of PBPK modelling to understand a clinical drug–drug interaction between dextromethorphan and GSK1034702
Abstract 1. In a clinical trial, a strong drug–drug interaction (DDI) was observed between dextromethorphan (DM, the object or… Expand
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2014
2014
An evaluation of the brain distribution of [11C]GSK1034702, a muscarinic-1 (M1) positive allosteric modulator in the living human brain using positron emission tomography
BackgroundThe ability to quantify the capacity of a central nervous system (CNS) drug to cross the human blood-brain barrier (BBB… Expand
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2013
2013
The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction.
Episodic memory deficits are a core feature of neurodegenerative disorders. Muscarinic M(1) receptors play a critical role in… Expand
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