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GSK 1034702
Known as:
GSK-1034702
, GSK1034702
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Benzimidazoles
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
S. Bradley
,
Colin Molloy
,
+12 authors
C. Langmead
Molecular Pharmacology
2018
Corpus ID: 21700508
The realization of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (mAChR) for the treatment of…
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2017
2017
Retrospective use of PBPK modelling to understand a clinical drug–drug interaction between dextromethorphan and GSK1034702
M. Hobbs
,
J. Bloomer
,
G. Dear
Xenobiotica; the fate of foreign compounds in…
2017
Corpus ID: 44635453
Abstract 1. In a clinical trial, a strong drug–drug interaction (DDI) was observed between dextromethorphan (DM, the object or…
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2014
2014
An evaluation of the brain distribution of [11C]GSK1034702, a muscarinic-1 (M1) positive allosteric modulator in the living human brain using positron emission tomography
K. Ridler
,
V. Cunningham
,
+10 authors
E. Rabiner
EJNMMI Research
2014
Corpus ID: 17822146
BackgroundThe ability to quantify the capacity of a central nervous system (CNS) drug to cross the human blood-brain barrier (BBB…
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Highly Cited
2013
Highly Cited
2013
The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction.
P. Nathan
,
J. Watson
,
+14 authors
E. Bullmore
The international journal of…
2013
Corpus ID: 2852923
Episodic memory deficits are a core feature of neurodegenerative disorders. Muscarinic M(1) receptors play a critical role in…
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