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National Institutes of Health
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Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
Corpus ID: 21700508
The realization of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (mAChR) for the treatment of…
Retrospective use of PBPK modelling to understand a clinical drug–drug interaction between dextromethorphan and GSK1034702
Xenobiotica; the fate of foreign compounds in…
Corpus ID: 44635453
Abstract 1. In a clinical trial, a strong drug–drug interaction (DDI) was observed between dextromethorphan (DM, the object or…
An evaluation of the brain distribution of [11C]GSK1034702, a muscarinic-1 (M1) positive allosteric modulator in the living human brain using positron emission tomography
Corpus ID: 17822146
BackgroundThe ability to quantify the capacity of a central nervous system (CNS) drug to cross the human blood-brain barrier (BBB…
The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction.
The international journal of…
Corpus ID: 2852923
Episodic memory deficits are a core feature of neurodegenerative disorders. Muscarinic M(1) receptors play a critical role in…
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