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Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands
An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands.
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Parametric Imaging of Ligand-Receptor Binding in PET Using a Simplified Reference Region Model
A method is presented for the generation of parametric images of radioligand-receptor binding using PET using a simplified reference region compartmental model, which requires no arterial blood sampling. Expand
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Evidence for striatal dopamine release during a video game
Dopaminergic neurotransmission may be involved in learning, reinforcement of behaviour, attention, and sensorimotor integration,. Binding of the radioligand 11C-labelled raclopride to dopamine D2Expand
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Spectral Analysis of Dynamic PET Studies
  • V. Cunningham, T. Jones
  • Computer Science, Medicine
  • Journal of cerebral blood flow and metabolism…
  • 1 January 1993
We describe a new technique for the analysis of dynamic positron emission tomography (PET) studies in humans, where data consist of the time courses of label in tissue regions of interest and in arterial blood, following the administration of radiolabeled tracers. Expand
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Positron Emission Tomography Compartmental Models
The current article presents theory for compartmental models used in positron emission tomography (PET). Both plasma input models and reference tissue input models are considered. General theory isExpand
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Measuring Drug Occupancy in the Absence of a Reference Region: The Lassen Plot Re-Visited
Quantitative estimation of neuroreceptor occupancy by exogenous drugs using positron emission tomography is based on the reduction in the total volume of distribution (VT) of site-specificExpand
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Positron Emission Tomography Compartmental Models: A Basis Pursuit Strategy for Kinetic Modeling
A kinetic modeling approach for the quantification of in vivo tracer studies with dynamic positron emission tomography (PET) is presented. Expand
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Compartmental Analysis of Diprenorphine Binding to Opiate Receptors in the Rat in vivo and its Comparison with Equilibrium Data in vitro
The regional binding of the opiate receptor ligand diprenorphine has been examined in rat brain both in vivo and in vitro. The time course of total label in specific brain regions was followed up toExpand
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Relationships between Extraction and Metabolism of Glucose, Blood Flow, and Tissue Blood Volume in Regions of Rat Brain
Studies were made on the relationships between the rate of glucose metabolism, the transport of glucose between plasma and brain, cerebral blood flow, and blood content. Conscious control rats wereExpand
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Gray matter blood flow change is unevenly distributed during moderate isocapnic hypoxia in humans.
Hypoxia increases cerebral blood flow (CBF), but it is unknown whether this increase is uniform across all brain regions. We used H(2)(15)O positron emission tomography imaging to measure absoluteExpand
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