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GS967

 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967
Many epilepsy patients are refractory to conventional antiepileptic drugs. Resurgent and persistent currents can be enhanced by… Expand
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2019
2019
Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene
BackgroundFamilial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. Three… Expand
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2018
2018
Effects of the Inhibition of Late Sodium Current by GS967 on Stretch-Induced Changes in Cardiac Electrophysiology
PurposeMechanical stretch increases sodium and calcium entry into myocytes and activates the late sodium current. GS967, a… Expand
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2017
2017
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome
Dravet syndrome, an epileptic encephalopathy affecting children, largely results from heterozygous loss-of-function mutations in… Expand
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2014
2014
Antiepileptic activity of preferential inhibitors of persistent sodium current
Evidence from basic neurophysiology and molecular genetics has implicated persistent sodium current conducted by voltage‐gated… Expand
2014
2014
Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts.
BACKGROUND Enhanced late inward Na current (INa-L) modulates action potential duration (APD) and plays a key role in the genesis… Expand
2014
2014
Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity.
BACKGROUND Ischemic heart disease is associated with dual risk for atrial and ventricular arrhythmias. OBJECTIVE We examined… Expand
2014
2014
Selective Inhibition of the Late Sodium Current has No Adverse Effect on Electrophysiological or Contractile Function of the Normal Heart
Abstract: Inhibition of cardiac late Na+ current (INa,L) decreases sodium-dependent calcium overload in diseased hearts. Because… Expand
Highly Cited
2013
Highly Cited
2013
A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental Arrhythmias
Inhibition of cardiac late sodium current (late INa) is a strategy to suppress arrhythmias and sodium-dependent calcium overload… Expand
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2013
2013
In silico assessment of drug safety in human heart applied to late sodium current blockers
Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti… Expand
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