FAQ

GS967

 

Topic mentions per year

Topic mentions per year

2013-2017
024620132017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.
Aims Selective inhibition of cardiac late sodium current (INaL) is an emerging target in the treatment of ventricular arrhythmias… (More)
Is this relevant?
2017
2017
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome
Dravet syndrome, an epileptic encephalopathy affecting children, largely results from heterozygous loss-of-function mutations in… (More)
Is this relevant?
2017
2017
Increment of late sodium currents in the left atrial myocytes and its potential contribution to increased susceptibility of atrial fibrillation in castrated male mice.
BACKGROUND The incidence of atrial fibrillation (AF) is correlated with decreased levels of testosterone in elderly men. Late… (More)
Is this relevant?
2014
2014
Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity.
BACKGROUND Ischemic heart disease is associated with dual risk for atrial and ventricular arrhythmias. OBJECTIVE We examined… (More)
Is this relevant?
2014
2014
Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts.
BACKGROUND Enhanced late inward Na current (INa-L) modulates action potential duration (APD) and plays a key role in the genesis… (More)
Is this relevant?
2014
2014
Selective inhibition of the late sodium current has no adverse effect on electrophysiological or contractile function of the normal heart.
Inhibition of cardiac late Na(+) current (I(Na,L)) decreases sodium-dependent calcium overload in diseased hearts. Because INa,L… (More)
Is this relevant?
2014
2014
Antiepileptic activity of preferential inhibitors of persistent sodium current.
OBJECTIVE Evidence from basic neurophysiology and molecular genetics has implicated persistent sodium current conducted by… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2013
2013
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias.
Inhibition of cardiac late sodium current (late I(Na)) is a strategy to suppress arrhythmias and sodium-dependent calcium… (More)
Is this relevant?
2013
2013
Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967.
BACKGROUND Previous studies have shown that late sodium channel current (INa) blockers such as ranolazine can exert… (More)
Is this relevant?
2013
2013
In silico assessment of drug safety in human heart applied to late sodium current blockers.
Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti… (More)
Is this relevant?