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GS967

 
National Institutes of Health

Papers overview

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2019
2019
Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene
BackgroundFamilial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. Three… Expand
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2017
2017
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome
Dravet syndrome, an epileptic encephalopathy affecting children, largely results from heterozygous loss-of-function mutations in… Expand
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2017
2017
Basal late sodium current is a significant contributor to the duration of action potential of guinea pig ventricular myocytes
In cardiac myocytes, an enhancement of late sodium current (INaL) under pathological conditions is known to cause prolongation of… Expand
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2014
2014
Antiepileptic activity of preferential inhibitors of persistent sodium current.
OBJECTIVE Evidence from basic neurophysiology and molecular genetics has implicated persistent sodium current conducted by… Expand
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2014
2014
Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts.
BACKGROUND Enhanced late inward Na current (INa-L) modulates action potential duration (APD) and plays a key role in the genesis… Expand
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2014
2014
Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity.
BACKGROUND Ischemic heart disease is associated with dual risk for atrial and ventricular arrhythmias. OBJECTIVE We examined… Expand
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2014
2014
Selective inhibition of the late sodium current has no adverse effect on electrophysiological or contractile function of the normal heart.
Inhibition of cardiac late Na(+) current (I(Na,L)) decreases sodium-dependent calcium overload in diseased hearts. Because INa,L… Expand
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2013
2013
In silico assessment of drug safety in human heart applied to late sodium current blockers.
Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti… Expand
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Highly Cited
2012
Highly Cited
2012
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias.
Inhibition of cardiac late sodium current (late I(Na)) is a strategy to suppress arrhythmias and sodium-dependent calcium… Expand
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2012
2012
Late Sodium Current Is an Intrinsic Regulator of Cardiac Repolarization—A Quantitative Assessment
Background Although enhancement of late Na + current (I NaL ) may cause prolongation of action potential duration (APD) in… Expand
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