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GS967

 
National Institutes of Health

Papers overview

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2020
2020
Many epilepsy patients are refractory to conventional antiepileptic drugs. Resurgent and persistent currents can be enhanced by… Expand
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2019
2019
BackgroundFamilial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. Three… Expand
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2018
2018
PurposeMechanical stretch increases sodium and calcium entry into myocytes and activates the late sodium current. GS967, a… Expand
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2017
2017
Dravet syndrome, an epileptic encephalopathy affecting children, largely results from heterozygous loss-of-function mutations in… Expand
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2014
2014
Evidence from basic neurophysiology and molecular genetics has implicated persistent sodium current conducted by voltage‐gated… Expand
2014
2014
BACKGROUND Enhanced late inward Na current (INa-L) modulates action potential duration (APD) and plays a key role in the genesis… Expand
2014
2014
BACKGROUND Ischemic heart disease is associated with dual risk for atrial and ventricular arrhythmias. OBJECTIVE We examined… Expand
2014
2014
Abstract: Inhibition of cardiac late Na+ current (INa,L) decreases sodium-dependent calcium overload in diseased hearts. Because… Expand
Highly Cited
2013
Highly Cited
2013
Inhibition of cardiac late sodium current (late INa) is a strategy to suppress arrhythmias and sodium-dependent calcium overload… Expand
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2013
2013
Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti… Expand