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GS967

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967
Many epilepsy patients are refractory to conventional antiepileptic drugs. Resurgent and persistent currents can be enhanced by… 
2019
2019
Increase of late sodium current contributes to enhanced susceptibility to atrial fibrillation in diabetic mice.
2019
2019
Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene
BackgroundFamilial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. Three… 
2017
2017
Increment of late sodium currents in the left atrial myocytes and its potential contribution to increased susceptibility of atrial fibrillation in castrated male mice.
Highly Cited
2017
Highly Cited
2017
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome
Dravet syndrome, an epileptic encephalopathy affecting children, largely results from heterozygous loss-of-function mutations in… 
2014
2014
Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts.
2014
2014
Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity.
Highly Cited
2014
Highly Cited
2014
Antiepileptic activity of preferential inhibitors of persistent sodium current
Evidence from basic neurophysiology and molecular genetics has implicated persistent sodium current conducted by voltage‐gated… 
Review
2013
Review
2013
The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.
This review presents the roles of cardiac sodium channel NaV1.5 late current (late INa) in generation of arrhythmic activity. The… 
Highly Cited
2013
Highly Cited
2013
A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental Arrhythmias
Inhibition of cardiac late sodium current (late INa) is a strategy to suppress arrhythmias and sodium-dependent calcium overload… 
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