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GRB7 gene

Known as: Growth Factor Receptor-Bound Protein 7 Gene, GRB7, GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7 
This gene is involved in signal transduction and protein binding.
National Institutes of Health

Related topics

Related topics

3 relations
Growth Factor Receptor-Bound Protein 7Signal Transductionprotein protein interaction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules.
Amplification of human Her2 and its aberrant signaling in 20-30% of early breast cancer patients is responsible for highly… 
Highly Cited
2012
Highly Cited
2012
Targeting GRB7/ERK/FOXM1 Signaling Pathway Impairs Aggressiveness of Ovarian Cancer Cells
Ovarian cancer is a highly lethal disease with poor prognosis and especially in high-grade tumor. Emerging evidence has reported… 
2012
2012
Expression screening of 17q12–21 amplicon reveals GRB7 as an ERBB2‐dependent oncogene
2010
2010
Dual action of epidermal growth factor: extracellular signal-stimulated nuclear–cytoplasmic export and coordinated translation of selected messenger RNA
EGF triggers dephosphorylation of the mRNA-binding protein Grb7 in the nucleus, leading to its export, and it also stimulates FAK… 
Highly Cited
2009
Highly Cited
2009
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.
PURPOSE We have previously identified a set of breast cancer antiestrogen resistance (BCAR) genes causing estrogen independence… 
Highly Cited
2008
Highly Cited
2008
Regulation of stress granule dynamics by Grb7 and FAK signalling pathway
Cells form stress granules (SGs) in response to environmental stresses, which constitute cytoplasmic domains where mRNAs are… 
Highly Cited
2006
Highly Cited
2006
Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis.
BACKGROUND Pancreatic cancer is one of the most aggressive malignancies, with high rates of invasion and metastasis and with… 
Highly Cited
2005
Highly Cited
2005
Activating mutations and/or expression levels of tyrosine kinase receptors GRB7, RAS, and BRAF in testicular germ cell tumors.
Amplification and/or overexpression of genes encoding tyrosine kinase receptors KIT and ERBB2 have been reported in testicular… 
2004
2004
Grb7 expression and cellular migration in chronic lymphocytic leukemia: a comparative study of early and advanced stage disease
Grb7, a noncatalytic intracellular adaptor protein involved in cell migration, is overexpressed in certain invasive and… 
Highly Cited
1999
Highly Cited
1999
Association of Focal Adhesion Kinase with Grb7 and Its Role in Cell Migration*
Focal adhesion kinase (FAK) has been implicated to play a key role in integrin-mediated signal transduction in cell migration… 
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