GRB14 protein, human

Known as: GRB14, Growth Factor Receptor-Bound Protein 14, growth factor receptor-bound protein 14, human 
Member of the GRB7 family of adapter proteins; identified as a partner of the insulin receptor where it acts as a modulator of insulin signaling… (More)
National Institutes of Health

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Broader (1)

Adaptor Proteins, Signal Transducing
Adaptor Signaling Protein GeneGRB14 geneSignal TransductionSignaling Pathway Gene
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Papers overview

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2009
2009
Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14
Growth factor receptor–binding proteins Grb7, Grb10 and Grb14 are adaptor proteins containing a Ras-associating (RA) domain, a… (More)
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Highly Cited
2006
Highly Cited
2006
GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle.
Obesity is associated with insulin resistance in skeletal muscle; accordingly, weight loss dramatically improves insulin action… (More)
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2005
2005
Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.
Grb14, a member of the Grb7 adaptor protein family, possesses a pleckstrin homology (PH) domain, a C-terminal Src homology-2 (SH2… (More)
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Highly Cited
2004
Highly Cited
2004
Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice.
Gene targeting was used to characterize the physiological role of growth factor receptor-bound (Grb)14, an adapter-type… (More)
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2004
2004
The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.
The metabolic actions of insulin are transduced through the phosphatidylinositol 3-kinase pathway. A critical component of this… (More)
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Review
2004
Review
2004
Regulation and functional roles of Grb14.
Grb14 is the last described member of the Grb7 family of adaptors, containing Grb7, Grb10 and Grb14. These proteins share a… (More)
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Highly Cited
2002
Highly Cited
2002
Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.
Grb14 belongs to the Grb7 family of adapters and was recently identified as a partner of the insulin receptor (IR). Here we show… (More)
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2001
2001
Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14.
Tankyrase is an ankyrin repeat-containing poly(ADP-ribose) polymerase originally isolated as a binding partner for the telomeric… (More)
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1998
1998
Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases.
Grb10 and its close homologues Grb7 and Grb14, belong to a family of adapter proteins characterized by a proline-rich region, a… (More)
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1996
1996
Cloning and characterization of GRB14, a novel member of the GRB7 gene family.
Screening of a human breast epithelial cell cDNA library with the tyrosine-phosphorylated C terminus of the epidermal growth… (More)
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