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GRB14 protein, human

Known as: GRB14, Growth Factor Receptor-Bound Protein 14, growth factor receptor-bound protein 14, human 
Member of the GRB7 family of adapter proteins; identified as a partner of the insulin receptor where it acts as a modulator of insulin signaling… Expand
National Institutes of Health

Related topics

Related topics

7 relations

Broader (1)

Adaptor Proteins, Signal Transducing
Adaptor Signaling Protein GeneGRB14 geneSignal TransductionSignaling Pathway Gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci
Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although… Expand
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Highly Cited
2006
Highly Cited
2006
GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle.
Obesity is associated with insulin resistance in skeletal muscle; accordingly, weight loss dramatically improves insulin action… Expand
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Highly Cited
2005
Highly Cited
2005
Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.
Grb14, a member of the Grb7 adaptor protein family, possesses a pleckstrin homology (PH) domain, a C-terminal Src homology-2 (SH2… Expand
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Highly Cited
2004
Highly Cited
2004
Improved glucose homeostasis and enhanced insulin signalling in Grb14‐deficient mice
Gene targeting was used to characterize the physiological role of growth factor receptor‐bound (Grb)14, an adapter‐type… Expand
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Highly Cited
2002
Highly Cited
2002
Identification of Novel Non-phosphorylated Ligands, Which Bind Selectively to the SH2 Domain of Grb7*
Grb7 is an adapter-type signaling protein, which is recruited via its SH2 domain to a variety of receptor tyrosine kinases (RTKs… Expand
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Highly Cited
2001
Highly Cited
2001
Identification of a Novel Human Tankyrase through Its Interaction with the Adaptor Protein Grb14*
Tankyrase is an ankyrin repeat-containing poly(ADP-ribose) polymerase originally isolated as a binding partner for the telomeric… Expand
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Highly Cited
2000
Highly Cited
2000
Association of Fibroblast Growth Factor Receptor 1 with the Adaptor Protein Grb14
Using the cytoplasmic domain of fibroblast growth factor receptor 1 (FGFR1) as bait in a yeast two-hybrid screen, Grb14 was… Expand
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Highly Cited
1998
Highly Cited
1998
Interaction of the Grb10 Adapter Protein with the Raf1 and MEK1 Kinases*
Grb10 and its close homologues Grb7 and Grb14, belong to a family of adapter proteins characterized by a proline-rich region, a… Expand
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Highly Cited
1998
Highly Cited
1998
Identification of the Rat Adapter Grb14 as an Inhibitor of Insulin Actions*
We cloned by interaction with the β-subunit of the insulin receptor the rat variant of the human adapter Grb14 (rGrb14). rGrb14… Expand
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Highly Cited
1998
Highly Cited
1998
Grb10 Interacts Differentially with the Insulin Receptor, Insulin-like Growth Factor I Receptor, and Epidermal Growth Factor Receptor via the Grb10 Src Homology 2 (SH2) Domain and a Second Novel…
The Grb10 protein appears to be an adapter protein of unknown function that has been implicated in insulin receptor (IR… Expand
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