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GR 89696

Known as: 1-Piperazinecarboxylic acid, 4-((3,4-dichlorophenyl)acetyl)-3-(1-pyrrolidinylmethyl)-, methyl ester, (E)-2-butenedioate (1:1), GR-89696 
 
National Institutes of Health

Related topics

Related topics

4 relations
GR 103545GR 85571

Broader (2)

PiperazinesPyrrolidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Role of dorsal hippocampus κ opioid receptors in contextual aversive memory consolidation in rats
&NA; The main &kgr; opioid receptors (&kgr;ORs) subtypes already described (&kgr;1ORs and &kgr;2ORs) are expressed in brain… Expand
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2010
2010
Comparative analysis of the cardioprotective properties of opioid receptor agonists in a rat model of myocardial infarction.
OBJECTIVES This study was conducted to test the hypothesis that opioid receptor (OR)-mediated cardioprotection is agonist… Expand
Highly Cited
2009
Highly Cited
2009
Effects of Atypical κ-Opioid Receptor Agonists on Intrathecal Morphine-Induced Itch and Analgesia in Primates
  • M. Ko, S. Husbands
  • Journal of Pharmacology and Experimental…
  • 2009
    • Corpus ID: 2035324
Itch/pruritus is the most common side effect associated with spinal administration of morphine given to humans for analgesia. The… Expand
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2009
2009
New method for the synthesis of methyl-4-[(3,4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)methyl]-1-piperazinecarboxylate
A new simple method involving a reduced number of steps is proposed for the synthesis of methyl-4-[(3, 4-dichlorophenyl)acetyl]-3… Expand
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2008
2008
Myocardial resistance to ischemic and reperfusion injuries under conditions of chronic administration of opioid receptor agonists and antagonists
Chronic treatment with opioid receptor ligands: nonselective peptide opioid receptor agonist dalargin (intraperitoneally in a… Expand
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1999
1999
Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat.
We examined whether increases in blood-brain barrier (BBB) permeability occurring after stroke can be exploited to apply… Expand
1999
1999
Maternal behaviour in sheep (Ovis aries) following administration of opioid agonists.
  • C. Cook
  • New Zealand veterinary journal
  • 1999
    • Corpus ID: 25444613
AIMS As kappa(kappa)-opioids have marked effects on pain threshold in sheep during oestrus, late pregnancy and after birth, a… Expand
1998
1998
Steroidal hormones determine sex-related differences in opioid-induced elevation of nociceptive threshold in sheep (Ovis aries).
  • C. Cook
  • New Zealand veterinary journal
  • 1998
    • Corpus ID: 23525604
AIMS As sex related differences in opioid-induced elevations of nociceptive thresholds have been observed in sheep, a study was… Expand
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