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GNE-317

National Institutes of Health

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PyrimidinesThiophenes

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2018
2018
PL - 028 Aerobic exercise inhibits tau hyperphosphorylation through activation of the PI3K/Akt pathway in the hippocampus of APP/PS1 mice
Objective Many studies suggest that regular physical exercise can reduce the risk of Alzheimer’s disease and slow its onset and… 
2014
2014
Abstract 2617: Preclinical efficacy of GNE-317, a dual PI3K/mTOR inhibitor, with or without bevacizumab in EGFR and/or PTEN-mutated glioblastoma multiforme
GNE-317 is a dual PI3K/mTOR inhibitor with excellent blood-brain barrier penetration. In this study, the efficacy of GNE-317 was… 
2014
2014
INFLUENCE OF DRUG DELIVERY ON THERAPEUTIC BENEFIT IN GBM–CDK4 AND MDM2 INHIBITOR COMPARISON IN FLANK VERSUS ORTHOTOPIC MODELS AND COMPARISON OF BRAIN PENETRANT VERSUS IMPENETRANT PI3K/MTOR INHIBITORS
BACKGROUND: Insufficient drug delivery across an intact blood-brain barrier (BBB) may limit the efficacy of therapeutic… 
2014
2014
Abstract 4479: Influence of the blood-brain barrier on drug distribution and efficacy of PI3K/mTOR inhibitors
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Drug delivery to glioblastoma multiforme (GBM) is… 
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