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GLTSCR2 gene

Known as: GLTSCR2, PICT-1, PICT1 
This gene plays a role in the regulation of protein phosphorylation and turnover.
National Institutes of Health

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3 relations
GLTSCR2 protein, humanProtein phosphorylation

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GLTSCR2 wt Allele

Papers overview

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2018
2018
Abnormal Expression of PICT-1 and Its Codon 389 Polymorphism Is a Risk Factor for Human Endometrial Cancer
Objective: The protein interacting with carboxyl terminus-1 (PICT-1) gene has been implicated as a tumor suppressor gene, and its… Expand
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2017
2017
Abstract 2574: The PICT-1 is required for USP7 to effectively stabilize p53 protein, and codon 389 polymorphism is a risk factor for ovarian cancer
The ovarian cancers causes the deaths of more than 100,000 women per year worldwide, and it is a complex disease, with multiple… Expand
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2017
2017
The protein interacting with carboxyl terminus‐1 codon 389 polymorphism impairs protein interacting with carboxyl terminus‐1 function and is a risk factor for uterine cervical cancer
PICT-1 is a nucleolar protein with various tumor suppressor functions. Recently, PICT-1 expression was reported to be… Expand
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2016
2016
PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway
PICT-1 was originally identified as a tumor suppressor. Here, we found that PICT-1 overexpression triggered pro-death autophagy… Expand
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2016
2016
PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway
PICT-1 is an essential ribosome biogenesis factor whose loss induces p53 accumulation and apoptosis. Here, we show that DNA… Expand
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2014
2014
The nucleolar PICT-1/GLTSCR2 protein forms homo-oligomers.
The human "protein interacting with carboxyl terminus 1" (PICT-1), also designated as the "glioma tumor suppressor candidate… Expand
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2013
2013
Clinical Significance of PICT1 in Patients of Hepatocellular Carcinoma with Wild-Type TP53
BackgroundTP53 is one of the most widely known cancer suppressor genes. Mutations in TP53 are ubiquitously observed in almost all… Expand
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2012
2012
Nucleolar Localization of GLTSCR2/PICT-1 Is Mediated by Multiple Unique Nucleolar Localization Sequences
The human glioma tumor suppressor candidate region 2 gene product, GLTSCR2, also called ‘protein interacting with carboxyl… Expand
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2006
2006
Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.
The tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates diverse cellular functions by… Expand
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Highly Cited
2004
Highly Cited
2004
Regulation of PTEN Phosphorylation and Stability by a Tumor Suppressor Candidate Protein*♦
The tumor suppressor PTEN plays an essential role in regulating signaling pathways involved in cell growth and apoptosis and is… Expand
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