FAQ

GLCE gene

Known as: GLCE, HEPARIN/HEPARAN SULFATE GLUCURONIC ACID C5-EPIMERASE, KIAA0836 
 

Topic mentions per year

Topic mentions per year

2005-2016
012320052016

Papers overview

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2016
2016
Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.
One of the key regulators of endochondral ossification is Indian hedgehog (Ihh), which acts as a long-range morphogen in the… (More)
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2015
2015
Structural and functional study of D-glucuronyl C5-epimerase.
Heparan sulfate (HS) is a glycosaminoglycan present on the cell surface and in the extracellular matrix, which interacts with… (More)
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2014
2014
GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling.
Neurodevelopment is orchestrated by a series of growth factor-HS (heparan sulfate) interactions which are involved in… (More)
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2014
2014
Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome
BACKGROUND The higher prevalence of Asperger Syndrome (AS) and other autism spectrum conditions in males has been known for many… (More)
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2013
2013
Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid.
During the biosynthesis of heparan sulfate (HS), glucuronyl C5-epimerase (Hsepi) catalyzes C5-epimerization of glucuronic acid… (More)
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2013
2013
A novel bacterial enzyme with D-glucuronyl C5-epimerase activity.
Glycosaminoglycans are biologically active polysaccharides that are found ubiquitously in the animal kingdom. The biosynthesis of… (More)
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Highly Cited
2010
Highly Cited
2010
MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling.
RATIONALE Establishment of a functional vasculature requires the interconnection and remodeling of nascent blood vessels. Precise… (More)
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2009
2009
Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling.
HSEPI (glucuronyl C5-epimerase) catalyzes the conversion of d-glucuronic acid to l-iduronic acid in heparan sulfate (HS… (More)
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2008
2008
Decreased expression of human D-glucuronyl C5-epimerase in breast cancer.
D-glucuronyl C5-epimerase (GLCE) is one of the key enzymes in proteoglycan biosynthesis. However, nothing is known about… (More)
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2005
2005
The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway.
Heparan sulphate (HS) is a ubiquitous constituent of the extracellular matrix that is required for the biological activity of… (More)
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