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Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice
A rheostat role for HIF-2α is proposed that allows for the maintenance of ROS as well as mitochondrial homeostasis and avoids multiple-organ pathology, biochemical abnormalities and altered gene expression patterns in mice lacking this family member. Expand
Growth factor–induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells
Results support a specific role for shed syndecan-1 or MMP7–syndecan -1 complexes in tumor progression and add to accumulating evidence that syndecans and glypicans have nonequivalent functions in vivo. Expand
HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner.
It is proposed that HIF-2alpha, encoded by the EPAS1 gene, is an essential regulator of murine erythropoietin production and may play a prominent role in conditions involving altered hematopoietic or ery Anthropogenic homeostasis. Expand
Structure elucidation and sulfated derivatives preparation of two alpha-D-glucans from Gastrodia elata Bl. and their anti-dengue virus bioactivities.
The structure-activity relationships (SAR) between the polysaccharides and their sulfated derivatives showed that the higher the DS is, the more potent the impact on the dengue virus infection would be. Expand
Hypoxia-inducible Factor 2α Regulates Expression of the Mitochondrial Aconitase Chaperone Protein Frataxin*
The studies reveal that Fxn, like Sod2, is a nuclear-encoded, mitochondrial-localized HIF-2α target gene required for optimal mitochondrial homeostasis and expand upon the previously defined role of Hif-2 α in the cellular response to oxidative stress. Expand
Structural and Functional Study of d-Glucuronyl C5-epimerase*
  • Yi Qin, J. Ke, +12 authors K. Ding
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 7 January 2015
The crystal structures of Glce in apo-form and in complex with heparin hexasaccharide, both in a stable dimer conformation are determined, advancing understanding of the key modification in HS biosynthesis. Expand
Evaluation of water soluble β-D-glucan from Auricularia auricular-judae as potential anti-tumor agent
In vivo tests showed that the AAG significantly inhibited tumor growth in a dose-dependent fashion, but not because of cytotoxicity, and could be considered as a candidate for possible anti-tumor drugs. Expand
Heparin Impairs Angiogenesis through Inhibition of MicroRNA-10b*
Heparin attenuates miR-10b expression and induces HoxD10 expression in vivo to inhibit angiogenesis and impair the growth of MDA-MB-231 tumor xenografts, providing insight into the molecular mechanism by which heparin and thrombin regulateAngiogenesis. Expand
Modulations of Glypican-1 Heparan Sulfate Structure by Inhibition of Endogenous Polyamine Synthesis
Spermine uptake in polyamine-deprived cells was reduced when NO/nitrite-generated degradation of heparan sulfate was inhibited, and the results suggest a functional interplay between glypican recycling, NO/Nitrite- generated heparin sulfate degradation, and polyamine uptake. Expand
Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme.
Results suggested that the fucoidan FP08S2 from brown seaweeds S. fusiforme could be a potent anti-angiogenic agent. Expand