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GL 331

Known as: GL-331, GL331 
An epipodophyllotoxin analogue possessing antineoplastic properties. GL331 binds to and inhibits topoisomerase II, resulting in the accumulation of… Expand
National Institutes of Health

Papers overview

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Review
2010
Review
2010
  • K. Lee
  • Journal of natural products
  • 2010
  • Corpus ID: 31552773
Medicinal plants have long been an excellent source of pharmaceutical agents. Accordingly, the long-term objectives of the author… Expand
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Highly Cited
2004
Highly Cited
2004
AbstractPurpose. GL331 is a new homolog of VP-16, and has demonstrated more efficacious anti-cancer activity in both the in vitro… Expand
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2004
2004
AbstractPurpose. Topoisomerase II (Topo II) preferentially cuts DNA at alternating purine-pyrimidine repeats. Different Topo II… Expand
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2004
2004
GL331 is a novel podophyllotoxin-derived compound and is more efficacious than its congener VP-16 in killing several types of… Expand
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2003
2003
Matrix metalloproteinase-9 (MMP-9) associates with cancer cell invasion and metastasis. CL1-5 cells, a human lung adenocarcinoma… Expand
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2003
2003
We have studied GL331's anti-cancer mechanisms by studying their effect on the tumor-induced angiogenesis. Human lung… Expand
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Highly Cited
1999
Highly Cited
1999
Beta-lapachone (beta-Lap) has been found to inhibit DNA topoisomerases (Topos) by a mechanism distinct from that of other… Expand
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1998
1998
Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme responsible for DNA strand breaks, has been recently suggested to be… Expand
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1997
1997
CDC 25 is a dual phosphatase responsible for dephosphorylation and, thus, activation of CDC 2 kinase in G2. Abnormal activation… Expand
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1996
1996
GL331 is a semisynthetic topoisomerase II inhibitor derived from a plant toxin podophyllotoxin. In 72-h exposure assays, LD50… Expand
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