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GL 331

Known as: GL-331, GL331 
An epipodophyllotoxin analogue possessing antineoplastic properties. GL331 binds to and inhibits topoisomerase II, resulting in the accumulation of… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Etoposide
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Podophyllotoxin derivatives: a patent review (2012 – 2014)
Introduction: Podophyllotoxin (PPT) is a naturally occurring antimitotic agent and an interesting lead in the development of… 
Review
2010
Review
2010
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
  • K. Lee
  • Journal of natural products
  • 2010
  • Corpus ID: 31552773
Medicinal plants have long been an excellent source of pharmaceutical agents. Accordingly, the long-term objectives of the author… 
Review
2008
Review
2008
A review on plant-derived natural products and their analogs with anti-tumor activity
Traditional medicines, including Chinese herbal formulations, can serve as the source of potential new drugs, and initial… 
Review
2005
Review
2005
Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents.
  • Youngjae You
  • Current pharmaceutical design
  • 2005
  • Corpus ID: 24801613
Podophyllotoxin is an antimitotic natural product. Its inhibitory activity on cell growth led to the development of the… 
Highly Cited
2004
Highly Cited
2004
A Novel Podophyllotoxin-Derived Compound GL331 Is More Potent than Its Congener VP-16 in Killing Refractory Cancer Cells
AbstractPurpose. GL331 is a new homolog of VP-16, and has demonstrated more efficacious anti-cancer activity in both the in vitro… 
Review
1999
Review
1999
Novel antitumor agents from higher plants
  • K. Lee
  • Medicinal research reviews
  • 1999
  • Corpus ID: 39056123
This review article describes research on cytotoxic natural products isolated from plant sources, primarily preclinical lead… 
Highly Cited
1999
Highly Cited
1999
Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor beta-lapachone-induced apoptosis through an oxidation-dependent pathway.
Beta-lapachone (beta-Lap) has been found to inhibit DNA topoisomerases (Topos) by a mechanism distinct from that of other… 
1998
1998
Bcl-2 prevents topoisomerase II inhibitor GL331-induced apoptosis is mediated by down-regulation of poly(ADP-ribose)polymerase activity
Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme responsible for DNA strand breaks, has been recently suggested to be… 
1997
1997
Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis.
CDC 25 is a dual phosphatase responsible for dephosphorylation and, thus, activation of CDC 2 kinase in G2. Abnormal activation… 
1996
1996
Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide.
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