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GL 331
Known as:
GL-331
, GL331
An epipodophyllotoxin analogue possessing antineoplastic properties. GL331 binds to and inhibits topoisomerase II, resulting in the accumulation of…
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Etoposide
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Podophyllotoxin derivatives: a patent review (2012 – 2014)
A. Kamal
,
S. Ali Hussaini
,
A. Rahim
,
Syed Riyaz
Expert opinion on therapeutic patents
2015
Corpus ID: 207474965
Introduction: Podophyllotoxin (PPT) is a naturally occurring antimitotic agent and an interesting lead in the development of…
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Review
2010
Review
2010
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
K. Lee
Journal of natural products
2010
Corpus ID: 31552773
Medicinal plants have long been an excellent source of pharmaceutical agents. Accordingly, the long-term objectives of the author…
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Review
2008
Review
2008
A review on plant-derived natural products and their analogs with anti-tumor activity
K. Dholwani
,
A. Saluja
,
A. Gupta
,
D. Shah
Indian journal of pharmacology
2008
Corpus ID: 22155990
Traditional medicines, including Chinese herbal formulations, can serve as the source of potential new drugs, and initial…
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Review
2005
Review
2005
Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents.
Youngjae You
Current pharmaceutical design
2005
Corpus ID: 24801613
Podophyllotoxin is an antimitotic natural product. Its inhibitory activity on cell growth led to the development of the…
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Highly Cited
2004
Highly Cited
2004
A Novel Podophyllotoxin-Derived Compound GL331 Is More Potent than Its Congener VP-16 in Killing Refractory Cancer Cells
Tze-Sing Huang
,
Chun-chung Lee
,
+6 authors
J. Whang-peng
Pharmaceutical Research
2004
Corpus ID: 34397931
AbstractPurpose. GL331 is a new homolog of VP-16, and has demonstrated more efficacious anti-cancer activity in both the in vitro…
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Review
1999
Review
1999
Novel antitumor agents from higher plants
K. Lee
Medicinal research reviews
1999
Corpus ID: 39056123
This review article describes research on cytotoxic natural products isolated from plant sources, primarily preclinical lead…
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Highly Cited
1999
Highly Cited
1999
Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor beta-lapachone-induced apoptosis through an oxidation-dependent pathway.
S. Shiah
,
S. Chuang
,
Y. Chau
,
S. Shen
,
M. Kuo
Cancer research
1999
Corpus ID: 23710967
Beta-lapachone (beta-Lap) has been found to inhibit DNA topoisomerases (Topos) by a mechanism distinct from that of other…
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1998
1998
Bcl-2 prevents topoisomerase II inhibitor GL331-induced apoptosis is mediated by down-regulation of poly(ADP-ribose)polymerase activity
M. Kuo
,
S. Shen
,
Chih-Hsin Yang
,
S. Chuang
,
A. Cheng
,
Tze-Sing Huang
Oncogene
1998
Corpus ID: 25694170
Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme responsible for DNA strand breaks, has been recently suggested to be…
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1997
1997
Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis.
T. Huang
,
C. Shu
,
W. Yang
,
J. Whang-peng
Cancer research
1997
Corpus ID: 21209958
CDC 25 is a dual phosphatase responsible for dephosphorylation and, thus, activation of CDC 2 kinase in G2. Abnormal activation…
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1996
1996
Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide.
T. Huang
,
C. Shu
,
+5 authors
J. Whang-peng
Cancer letters
1996
Corpus ID: 36801980
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