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GL 331

Known as: GL-331, GL331 
An epipodophyllotoxin analogue possessing antineoplastic properties. GL331 binds to and inhibits topoisomerase II, resulting in the accumulation of… 
National Institutes of Health

Papers overview

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Review
2015
Review
2015
Introduction: Podophyllotoxin (PPT) is a naturally occurring antimitotic agent and an interesting lead in the development of… 
Review
2010
Review
2010
  • K. Lee
  • Journal of natural products
  • 2010
  • Corpus ID: 31552773
Medicinal plants have long been an excellent source of pharmaceutical agents. Accordingly, the long-term objectives of the author… 
Review
2008
Review
2008
Traditional medicines, including Chinese herbal formulations, can serve as the source of potential new drugs, and initial… 
Review
2005
Review
2005
  • Youngjae You
  • Current pharmaceutical design
  • 2005
  • Corpus ID: 24801613
Podophyllotoxin is an antimitotic natural product. Its inhibitory activity on cell growth led to the development of the… 
Highly Cited
2004
Highly Cited
2004
AbstractPurpose. GL331 is a new homolog of VP-16, and has demonstrated more efficacious anti-cancer activity in both the in vitro… 
Review
1999
Review
1999
  • K. Lee
  • Medicinal research reviews
  • 1999
  • Corpus ID: 39056123
This review article describes research on cytotoxic natural products isolated from plant sources, primarily preclinical lead… 
Highly Cited
1999
Highly Cited
1999
Beta-lapachone (beta-Lap) has been found to inhibit DNA topoisomerases (Topos) by a mechanism distinct from that of other… 
1998
1998
Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme responsible for DNA strand breaks, has been recently suggested to be… 
1997
1997
CDC 25 is a dual phosphatase responsible for dephosphorylation and, thus, activation of CDC 2 kinase in G2. Abnormal activation…