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GL 331

Known as: GL-331, GL331 
An epipodophyllotoxin analogue possessing antineoplastic properties. GL331 binds to and inhibits topoisomerase II, resulting in the accumulation of… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Etoposide
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
  • K. Lee
  • Journal of natural products
  • 2010
    • Corpus ID: 31552773
Medicinal plants have long been an excellent source of pharmaceutical agents. Accordingly, the long-term objectives of the author… Expand
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Highly Cited
2004
Highly Cited
2004
A Novel Podophyllotoxin-Derived Compound GL331 Is More Potent than Its Congener VP-16 in Killing Refractory Cancer Cells
AbstractPurpose. GL331 is a new homolog of VP-16, and has demonstrated more efficacious anti-cancer activity in both the in vitro… Expand
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2004
2004
A Novel Topoisomerase II Poison GL331 Preferentially Induces DNA Cleavage at (C/G)T Sites and Can Cause Telomere DNA Damage
AbstractPurpose. Topoisomerase II (Topo II) preferentially cuts DNA at alternating purine-pyrimidine repeats. Different Topo II… Expand
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2004
2004
In vitro evaluation of GL331's cancer cell killing and apoptosis-inducing activity in combination with other chemotherapeutic agents
GL331 is a novel podophyllotoxin-derived compound and is more efficacious than its congener VP-16 in killing several types of… Expand
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2003
2003
Shortening of microsatellite deoxy(CA) repeats involved in GL331-induced down-regulation of matrix metalloproteinase-9 gene expression.
Matrix metalloproteinase-9 (MMP-9) associates with cancer cell invasion and metastasis. CL1-5 cells, a human lung adenocarcinoma… Expand
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2003
2003
GL331 inhibits HIF-1alpha expression in a lung cancer model.
We have studied GL331's anti-cancer mechanisms by studying their effect on the tumor-induced angiogenesis. Human lung… Expand
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Highly Cited
1999
Highly Cited
1999
Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor beta-lapachone-induced apoptosis through an oxidation-dependent pathway.
Beta-lapachone (beta-Lap) has been found to inhibit DNA topoisomerases (Topos) by a mechanism distinct from that of other… Expand
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1998
1998
Bcl-2 prevents topoisomerase II inhibitor GL331-induced apoptosis is mediated by down-regulation of poly(ADP-ribose)polymerase activity
Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme responsible for DNA strand breaks, has been recently suggested to be… Expand
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1997
1997
Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis.
CDC 25 is a dual phosphatase responsible for dephosphorylation and, thus, activation of CDC 2 kinase in G2. Abnormal activation… Expand
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1996
1996
Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide.
GL331 is a semisynthetic topoisomerase II inhibitor derived from a plant toxin podophyllotoxin. In 72-h exposure assays, LD50… Expand
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