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GL 331

Known as: GL-331, GL331 
An epipodophyllotoxin analogue possessing antineoplastic properties. GL331 binds to and inhibits topoisomerase II, resulting in the accumulation of… 
National Institutes of Health

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Broader (1)

Etoposide
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Induction of cell cycle arrest by GL331 via triggering an ATM-dependent DNA damage response in HepG2 cells
GL331, a topoisomerase II inhibitor, has been found to trigger DNA damage response (DDR) to induce cell cycle arrest. However… 
2008
2008
[Mechanism of regulation of leptin expression in human lung adenocarcinoma cells by hypoxia inducible factor-1alpha: a preliminary study].
OBJECTIVE To investigate the regulation of leptin expression in human lung adenocarcinoma cells by hypoxia inducible factor-1… 
2006
2006
GL331, a topoisomerase II inhibitor, induces radiosensitization of human glioma cells.
BACKGROUND GL331 is a topoisomerase II inhibitor and its effects on cultured human T98G glioma cells were investigated in this… 
2005
2005
Induction of apoptosis and cell cycle arrest in glioma cells by GL331 (a topoisomerase II inhibitor).
BACKGROUND GL331 is a topoisomerase II inhibitor and, in this study, the effects of GL331 upon rat C6 glioma cells were… 
2004
2004
Antitumor agents. Part 235: Novel 4'-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential.
2002
2002
Phase II and pharmacokinetic study of GL331 in previously treated Chinese gastric cancer patients
Abstract.Purpose: A phase II and pharmacokinetic study was designed to assess the efficacy and toxicity profile of an… 
2001
2001
Evaluation of GL331 in combination with paclitaxel: GL331's interference with paclitaxel-induced cell cycle perturbation and apoptosis
Combination of selecting agents that act on different cellular mechanisms is a common strategy in cancer chemotherapy. GL331 is a… 
2000
2000
In vitro evaluation of GL331's cancer cell killing and apoptosis-inducing activity in combination with other chemotherapeutic agents
GL331 is a novel podophyllotoxin-derived compound and is more efficacious than its congener VP-16 in killing several types of… 
1999
1999
Differential in vitro interactions of a series of clinically useful topoisomerase-interacting compounds with the cleavage/religation activity of the human topoisomerase IIalpha and IIbeta isoforms.
The topoisomerase II (TOP2)-associated DNA cleavage activity and the DNA sequence preference of 20 antitumor drugs, including 15… 
1996
1996
GL331-induced disruption of cyclin B1/CDC 2 complex and inhibition of CDC 2 kinase activity
GL331, a new homologue of etoposide (VP-16), was developed to cope with the multiple drug resistance occurring in certain… 
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