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Recent advances in the investigation of curcuminoids
TLDR
The literature between 1976 and mid-2008 on the anti-inflammatory, anti-oxidant,Anti-HIV, chemopreventive and anti-prostate cancer effects of curcuminoids are reviewed. Expand
Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra.
TLDR
Compound 1 appears to be the first example of a flavonol to exhibit potent inhibition of tubulin polymerization and, therefore, warrants further investigation as an antimitotic agent. Expand
Anti-AIDS agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.
TLDR
Compound 1 shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml and the structure was elucidated by spectroscopic methods, including the concerted application of a number of 2D nmr techniques. Expand
Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine
TLDR
This article will review selected herbal products used in traditional Chinese medicine, including medicinal mushrooms, with emphasis on the most recent progress in research for the period of 2003 to 2011. Expand
Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds.
TLDR
Salaspermic acid, an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells, was isolated from the roots of Tripterygium wilfordii for the first time and a structure-activity correlation with ten related compounds indicated that the acetal linkage in ring A and the carboxyl group in ring E of 1 may be required for the anti-HIV activity. Expand
Structural analogs of tylophora alkaloids may not be functional analogs.
TLDR
Although tylophora alkaloids are structural analogs, their potency of cytotoxicity, selectivity against NF-kappaB signaling pathway, and their inhibitory effects against protein and nucleic acid synthesis are different. Expand
Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects.
TLDR
Among all evaluated curcumin derivatives, compound 2 showed the best inhibitory effects on both wild-type and mutant EGFR by efficiently inducing gefitinib-insensitive EGFR degradation. Expand
Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2',2'-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents.
TLDR
Quantitative structure-activity relationship (QSAR) modeling results were first performed on this compound type, and the models should aid in design of future anti-HIV DCP analogs and potential clinical drug candidates. Expand
Recent progress in the development of tubulin inhibitors as antimitotic antitumor agents.
TLDR
This review will describe the recent progress being made in the development of novel antimitotic antitumor tubulin inhibitors and the emphasis has been placed on related research in the author's laboratory, including development of colchicine derivatives and other col chicine binding site drugs, such as flavonoids and quinolone derivatives. Expand
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