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GKT137831

National Institutes of Health

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2 relations

Broader (2)

PyrazolesPyridines

Papers overview

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2017
2017
Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1
ABSTRACT NADPH oxidase 4 (NOX4) and the NOX4-related redox signaling are implicated in cardiac hypertrophy. NOX4 is interrelated… 
2017
2017
Biphasic augmentation of alpha-adrenergic contraction by plumbagin in rat systemic arteries
Plumbagin, a hydroxy 1,4-naphthoquinone compound from plant metabolites, exhibits anticancer, antibacterial, and antifungal… 
2016
2016
NADPH Oxidase 4 at the Nexus of Diabetes, Reactive Oxygen Species, and Renal Metabolism.
NADPH oxidases (NOXs) catalyze the transfer of electrons from NADPH to molecular oxygen to produce superoxide and/or hydrogen… 
2015
2015
Personalizing pancreatic cancer organoids with hPSCs
A new study using human pluripotent stem cell (hPSC)-derived human pancreatic organoids to model neoplastic transformation and… 
2013
2013
Accelerated Atherosclerosis − NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus
Chin-Dusting, Rhian M. Touyz, Kirstin Wingler, Mark E. Cooper, Harald H. H. W. Schmidt and Montezano, Judy B. de Haan, Christine… 
2013
2013
Abstract 74: The Nox4 Inhibitor GKT137831, Prevents Aldosterone Production by Adipocytes and Protects Against Adipose Tissue Inflammation and Fibrosis in Obese Mice
Aldosterone (aldo) plays an important role in obesity-associated cardiovascular risk. We demonstrated that aldo is produced by… 
Review
2013
Review
2013
BLOCKING THE NADPH OXIDASE Nox 4 ACTIVITY PROVIDES RENOPROTECTION IN LONG TERM DIABETIC NEPHROPATHY
001 INTERLEUKIN 17RECEPTOR A (IL-17RA) ON LEUKOCYTES AND TISSUE CELLS MEDIATES INFLAMMATION IN A MURINE MODEL OF CRESCENTIC… 
2013
2013
Impaired epithelium in asthma : mechanisms driving ciliary dysfunction
i Impaired epithelium in asthma: mechanisms driving ciliary dysfunction Wing Yan Heidi Wan Abstract Rationale Epithelial ciliary… 
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