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GIMAP5 gene

Known as: IMAP3, GTPase, IMAP family member 5, IAN4L1 
 
National Institutes of Health

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GIMAP1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Gimap3 and Gimap5 cooperate to maintain T‐cell numbers in the mouse
Gimap3 (IAN4) and Gimap5 (IAN5) are highly homologous GTP‐binding proteins of the Gimap family. Gimap3 and Gimap5, whose… Expand
2011
2011
Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells
HSCs lacking the guanosine nucleotide-binding protein Gimap5, which stabilizes expression of the Mcl-1 Bcl2 family protein… Expand
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2010
2010
The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein.
A mutation in the rat GIMAP5 gene predisposes for autoimmunity, most famously in the BB rat model of autoimmune type 1 diabetes… Expand
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2009
2009
Loss of GIMAP5 (GTPase of immunity-associated nucleotide binding protein 5) impairs calcium signaling in rat T lymphocytes.
The recessive lyp allele, which harbors a defective gimap5 (GTPase of immunity-associated nucleotide binding protein 5) gene… Expand
2009
2009
IAN5 polymorphisms are associated with systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a representative autoimmune disease, which is frequently associated with lymphopenia… Expand
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Highly Cited
2008
Highly Cited
2008
Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5.
The loss of Gimap5 (GTPase of the immune-associated protein 5) gene function is the underlying cause of lymphopenia and… Expand
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2007
2007
Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells.
Gimap5, a member of the GTPase of the immunity-associated protein family (Gimap), regulates T cell survival. A strong indication… Expand
Highly Cited
2006
Highly Cited
2006
IAN Family Critically Regulates Survival and Development of T Lymphocytes
The IAN (immune-associated nucleotide-binding protein) family is a family of functionally uncharacterized GTP-binding proteins… Expand
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Review
2004
Review
2004
Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
For many years, the vast amount of data gathered from analysis of nonobese diabetic (NOD) and congenic NOD mice has eclipsed… Expand
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Highly Cited
2002
Highly Cited
2002
Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.
The BB (BioBreeding) rat is one of the best models of spontaneous autoimmune diabetes and is used to study non-MHC loci… Expand
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