GIMAP5 gene

Known as: IMAP3, GTPase, IMAP family member 5, IAN4L1 
 
National Institutes of Health

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GIMAP1 gene

Papers overview

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2015
2015
GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes
Long-term survival of T lymphocytes in quiescent state is essential to maintain their cell numbers in secondary lymphoid organs… (More)
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2010
2010
The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein.
A mutation in the rat GIMAP5 gene predisposes for autoimmunity, most famously in the BB rat model of autoimmune type 1 diabetes… (More)
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2010
2010
Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.
Rodents homozygous for autosomal leptin receptor gene mutations not only become obese, insulin resistant, and hyperleptinemic but… (More)
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2009
2009
Loss of GIMAP5 (GTPase of immunity-associated nucleotide binding protein 5) impairs calcium signaling in rat T lymphocytes.
The recessive lyp allele, which harbors a defective gimap5 (GTPase of immunity-associated nucleotide binding protein 5) gene… (More)
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2008
2008
Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5.
The loss of Gimap5 (GTPase of the immune-associated protein 5) gene function is the underlying cause of lymphopenia and… (More)
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2007
2007
Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells.
Gimap5, a member of the GTPase of the immunity-associated protein family (Gimap), regulates T cell survival. A strong indication… (More)
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Highly Cited
2006
Highly Cited
2006
IAN Family Critically Regulates Survival and Development of T Lymphocytes
The IAN (immune-associated nucleotide-binding protein) family is a family of functionally uncharacterized GTP-binding proteins… (More)
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2006
2006
Introgression of F344 rat genomic DNA on BB rat chromosome 4 generates diabetes-resistant lymphopenic BB rats.
Failure to express the Gimap5 protein is associated with lymphopenia (lyp) and linked to spontaneous diabetes in the diabetes… (More)
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Review
2004
Review
2004
Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
For many years, the vast amount of data gathered from analysis of nonobese diabetic (NOD) and congenic NOD mice has eclipsed… (More)
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Highly Cited
2002
Highly Cited
2002
Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.
The BB (BioBreeding) rat is one of the best models of spontaneous autoimmune diabetes and is used to study non-MHC loci… (More)
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