• Publications
  • Influence
Block of TRPC5 channels by 2‐aminoethoxydiphenyl borate: a differential, extracellular and voltage‐dependent effect
1 2‐Aminoethoxydiphenyl borate (2‐APB) has been widely used to examine the roles of inositol 1,4,5‐trisphosphate receptors (IP3Rs) and store‐operated Ca2+ entry and is an emerging modulator ofExpand
  • 209
  • 22
On the molecular basis and regulation of cellular capacitative calcium entry: roles for Trp proteins.
During the last 2 years, our laboratory has worked on the elucidation of the molecular basis of capacitative calcium entry (CCE) into cells. Specifically, we tested the hypothesis that CCE channelsExpand
  • 364
  • 21
trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry
SUMMARY Capacitative calcium entry (CCE) describes CA2+ influx into cells that replenishes CA2+ stores emptied through the action of IP3 and other agents. It is an essential component of cellularExpand
  • 600
  • 20
Cloning and Expression of a Novel Mammalian Homolog ofDrosophila Transient Receptor Potential (Trp) Involved in Calcium Entry Secondary to Activation of Receptors Coupled by the Gq Class of G Protein*
Hormonal stimulation of Gq-protein coupled receptors triggers Ca2+ mobilization from internal stores. This is followed by a Ca2+ entry through the plasma membrane.Drosophila Trp and Trpl proteinsExpand
  • 319
  • 18
  • Open Access
Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel.
Capacitative Ca2+ entry (CCE) is Ca2+ entering after stimulation of inositol 1,4,5-trisphosphate (IP3) formation and initiation of Ca2+ store depletion. One hallmark of CCE is that it can also beExpand
  • 250
  • 12
Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store
Homologues of Drosophilia transient receptor potential (TRP) have been proposed to be unitary subunits of plasma membrane ion channels that are activated as a consequence of active or passiveExpand
  • 336
  • 11
Ionic currents underlying HTRP3 mediated agonist‐dependent Ca2+ influx in stably transfected HEK293 cells
hTrp3 is a human homologue of the Drosophila gene responsible for a transient receptor potential (trp) mutation. When stably expressed in HEK293 cells, hTrp3 formed ion channels that were activeExpand
  • 103
  • 9
Multiple neurological abnormalities in mice deficient in the G protein Go.
The G protein Go is highly expressed in neurons and mediates effects of a group of rhodopsin-like receptors that includes the opioid, alpha2-adrenergic, M2 muscarinic, and somatostatin receptors. InExpand
  • 198
  • 8
  • Open Access
Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice.
G proteins are involved in cellular signalling and regulate a variety of biological processes including differentiation and development. We have generated mice deficient for the G protein subunitExpand
  • 155
  • 8
Exocytotic Insertion of TRPC6 Channel into the Plasma Membrane upon Gq Protein-coupled Receptor Activation*
TRPC proteins are the mammalian homologues of the Drosophila transient receptor potential channel and are involved in calcium entry after agonist stimulation of non-excitable cells. Seven mammalianExpand
  • 170
  • 7