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GHR wt Allele

Known as: GHBP, Growth Hormone Receptor wt Allele 
Human GHR wild-type allele is located within 5p13-p12 and is approximately 302 kb in length. This allele, which encodes growth hormone receptor… 
National Institutes of Health

Related topics

Related topics

11 relations
5p13-p12AKT Signaling PathwayCell Proliferation Regulatory ProcessGrowth

Papers overview

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Highly Cited
2001
Highly Cited
2001
Clinical and Endocrine Characteristics in Atypical and Classical Growth Hormone Insensitivity Syndrome
Objective: Classical growth hormone insensitivity syndrome (GHIS) comprises a dysmorphic phenotype, extreme short stature (height… 
Review
2000
Review
2000
Clinical review 112: Does serum growth hormone (GH) binding protein reflect human GH receptor function?
Previous observations raised the possibility that circulating GH-binding protein (GHBP) may serve as a useful index for tissue GH… 
Highly Cited
1998
Highly Cited
1998
Serum concentrations of insulin, insulin‐like growth factor(IGF)‐I, IGF binding protein (IGFBP)‐1 and ‐3 and growth hormone binding protein in obese children: fasting IGFBP‐1 is suppressed in…
Simple obesity is characterized by normal or accelerated growth in the presence of reduced serum levels of GH, whereas its… 
Highly Cited
1995
Highly Cited
1995
Reduced liver insulin-like growth factor-I gene expression in young zinc-deprived rats is associated with a decrease in liver growth hormone (GH) receptors and serum GH-binding protein.
Zinc depletion attenuates growth and decreases circulating IGF-I. To investigate the mechanisms responsible for the IGF-I decline… 
Highly Cited
1994
Highly Cited
1994
Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat.
Abnormalities of GH secretion and clearance are well-documented in poorly controlled insulin-dependent diabetes mellitus (IDDM… 
Highly Cited
1993
Highly Cited
1993
Growth hormone binding protein in the rat: effects of gonadal steroids.
In normal rats, females have higher circulating GH-binding protein (GHBP) levels than males, whereas in the GH-deficient dwarf… 
1992
1992
Identification and partial purification of serum growth hormone binding protein in domestic animal species.
The chemical nature and variations in serum concentrations of growth hormone binding protein (GHBP) from humans, rabbits, and… 
Highly Cited
1992
Highly Cited
1992
Diminished growth hormone-binding protein in children with insulin-dependent diabetes mellitus.
Two distinct GH-binding proteins (GHBP) are present in circulation in the human. The major GHBP (high affinity GHBP) is… 
Highly Cited
1992
Highly Cited
1992
Tissue-Specific Developmental Regulation of the Messenger Ribonucleic Acids Encoding the Growth Hormone Receptor and the Growth Hormone Binding Protein in Rat Fetal and Postnatal Tissues
ABSTRACT: Tissue responsiveness to growth hormone is likely to be regulated by local concentrations and availability of the… 
1992
1992
Growth hormone (GH)-binding protein in normal and GH-deficient dwarf rats.
There are GH-binding proteins (GHBPs) present in the blood of many species, and these correspond to the extracellular GH-binding… 
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