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GGTI 286

Known as: GGTI-286, GGTI286 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Leucine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The Role of RhoA in Neovascular-Related Functions of Endothelial Progenitor Cells Induced by AngiotensinⅡ
Background/Aims: Interference with endothelial progenitor cell (EPC) neovascularization is a novel therapeutic target for… 
2015
2015
Atorvastatin reduces long pentraxin 3 expression in vascular cells by inhibiting protein geranylgeranylation.
2015
2015
Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells.
Through the regulation of the RhoA/Rho kinase (ROCK) pathway, angiotensin II (Ang II)-induced fibrotic responses contribute to… 
Highly Cited
2011
Highly Cited
2011
The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle.
Smooth muscle cells promote fibroproliferative airway remodeling in asthma, and transforming growth factor β1 (TGFβ1) is a key… 
2010
2010
Pamidronate inhibits antiapoptotic bcl-2 expression through inhibition of the mevalonate pathway in prostate cancer PC-3 cells.
2008
2008
Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression
Objective Toll-like receptor 4 (TLR4) is the main receptor for Lipopolysaccharide (LPS). Two relatively common variants of the… 
2008
2008
The geranylgeranyl‐transferase inhibitor GGTI‐286 does not reproduce rosuvastatin‐induced delayed preconditioning against oxygen‐glucose deprivation (OGD) in cultured rat cortical neurons
Rosuvastatin (RST) has been recently shown to induce resistance against OGD via depletion of geranylgeranyl pyrophosphate (GGPP… 
2007
2007
Pamidronate down-regulates urokinase-type plasminogen activator expression in PC-3 prostate cancer cells.
BACKGROUND Bisphosphonates are considered to be effective in preventing tumor metastasis to bone. Urokinase-type plasminogen… 
2006
2006
Incadronate inhibits aminopeptidase N expression in prostatic PC-3 cells.
2003
2003
Pharmacological modulation of fatty acid desaturation and of cholesterol biosynthesis in THP-1 cells
In THP-1 cells, simvastatin decreases, in a concentration-dependent manner, cholesterol synthesis and increases linoleic acid (LA… 
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