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GGTA1P gene

Known as: glycoprotein, alpha-galactosyltransferase 1 pseudogene, GGTA1P, GGTA1 
National Institutes of Health

Related topics

Related topics

3 relations
GGTA2P geneGalactosyltransferasesN-acetyllactosaminide alpha-1,3-galactosyltransferase

Papers overview

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Highly Cited
2019
Highly Cited
2019
Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2
Cell surface carbohydrate antigens play a major role in the rejection of porcine xenografts. The most important for human… 
2017
2017
Generation of GGTA1 Mutant Pigs by Direct Pronuclear Microinjection of CRISPR/Cas9 Plasmid Vectors
ABSTRACT This study was conducted to confirm that 1-site and 4-site ppU6-GGTA1-gRNA CRISPR vectors together with the pCX-Flag2… 
Highly Cited
2016
Highly Cited
2016
Efficient production of biallelic GGTA1 knockout pigs by cytoplasmic microinjection of CRISPR/Cas9 into zygotes
Xenotransplantation is considered to be a promising solution to the growing demand for suitable donor organs for transplantation… 
2016
2016
Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation
The future of solid organ transplantation is challenged by an increasing shortage of available allografts. Xenotransplantation of… 
Highly Cited
2015
Highly Cited
2015
Evaluation of human and non‐human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes
Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The… 
Highly Cited
2002
Highly Cited
2002
Induction of Cytolytic Anti-Gal Antibodies in α-1,3-Galactosyltransferase Gene Knockout Mice by Oral Inoculation with Escherichia coli O86:B7 Bacteria
ABSTRACT Naturally occurring antibodies against [Gal α-1,3-Gal] structures (anti-Gal antibodies) are the primary effectors of… 
Highly Cited
2002
Highly Cited
2002
Structural Basis of Ordered Binding of Donor and Acceptor Substrates to the Retaining Glycosyltransferase, α-1,3-Galactosyltransferase*
Bovine α-1,3-galactosyltransferase (α3GT) catalyzes the synthesis of the α-galactose (α-Gal) epitope, the target of natural human… 
Highly Cited
1993
Highly Cited
1993
Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes.
A major problem with pig-to-human-tissue xenograft studies is that humans have natural antibodies to pig cells; these antibodies… 
Highly Cited
1993
Highly Cited
1993
Mutational analysis of the Golgi retention signal of bovine beta-1,4-galactosyltransferase.
Highly Cited
1991
Highly Cited
1991
Gene sequences suggest inactivation of alpha-1,3-galactosyltransferase in catarrhines after the divergence of apes from monkeys.
The glycosylation enzyme alpha-1,3-galactosyltransferase (alpha 1,3GT; UDPgalactose:beta-D-galactosyl-1,4-N-acetyl-D… 
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