FAQ

GDP-Mannose 4,6 Dehydratase, human

Known as: EC 4.2.1.47, Short Chain Dehydrogenase/Reductase Family 3E, Member 1, GDP-Mannose 4,6-Dehydratase 
GDP-mannose 4,6 dehydratase (372 aa, ~42 kDa) is encoded by the human GMDS gene. This protein is involved in the metabolism of nucleotide-sugar… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2012
0119802012

Related topics

Related topics

5 relations
Enzyme GeneGMDS geneLyase GeneNucleotide Metabolism
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Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
GDP-Mannose 4,6 Dehydratase, human
Signal Transduction
Nucleotide Metabolism
Enzyme Gene
GMDS gene
Lyase Gene

Papers overview

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2012
2012
Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila.
Notch (N) is a transmembrane receptor that mediates cell-cell interactions to determine many cell-fate decisions. N contains EGF… (More)
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2006
2006
Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.
The deoxyhexose sugar fucose has an important fine-tuning role in regulating the functions of glycoconjugates in disease and… (More)
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2001
2001
Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T.
The glycan repeats of the surface layer glycoprotein of Aneurinibacillus thermoaerophilus L420-91T contain d-rhamnose and 3… (More)
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2000
2000
Conservation of seven genes involved in the biosynthesis of the lipopolysaccharide O-side chain in Brucella spp.
Seven genes of the wb locus of Brucella melitensis 16M involved in the biosynthesis of the lipopolysaccharide O-side chain have… (More)
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1999
1999
Decreased availability of GDP-L-fucose in a patient with LAD II with normal GDP-D-mannose dehydratase and FX protein activities.
Leukocyte adhesion deficiency type II (LAD II) is caused by a disorder in the metabolism of GDP-L-fucose, which causes… (More)
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1997
1997
Expression, purification and characterization of GDP-D-mannose 4,6-dehydratase from Escherichia coli.
GDP-D-mannose dehydratase (GMD) catalyzes the first step of the pathway that converts GDP-D-mannose to GDP-L-fucose in bacteria… (More)
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1986
1986
Two Chinese hamster ovary glycosylation mutants affected in the conversion of GDP-mannose to GDP-fucose.
A biochemical basis for the pea and lentil lectin resistance of two Chinese hamster ovary (CHO) cell mutants, Lec13 and Lec13A… (More)
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1980
1980
Mouse lymphoma cell lines resistant to pea lectin are defective in fucose metabolism.
Two mutants of the BW5147 mouse lymphoma cell line have been selected for their resistance to the toxic effects of pea lectin… (More)
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