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GDP-L-fucose synthase activity

Known as: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity, GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing), GDP-fucose synthetase activity 
Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+. [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN]
National Institutes of Health

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GDP-L-fucose biosynthetic process

Papers overview

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2016
2016
Multienzymatic cascade synthesis of fucosyloligosaccharide via a two-step fermentation strategy in Escherichia coli
ObjectivesTo achieve multienzymatic cascade synthesis of fucosyl oligosaccharide from d-mannose by two-step fermentation pathway… Expand
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2008
2008
Deciphering the Genetic Bases of the Structural Diversity of Phenolic Glycolipids in Strains of the Mycobacterium tuberculosis Complex*
Phenolic glycolipids (PGL) play a major role in the virulence of mycobacteria, notably in strains of the Mycobacterium… Expand
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Highly Cited
2007
Highly Cited
2007
A high expression of GDP-fucose transporter in hepatocellular carcinoma is a key factor for increases in fucosylation.
Changes in the levels of fucosylation regulate the biological phenotype of cancer cells and a specific fucosylation, such as… Expand
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2004
2004
Biosynthesis of colitose: expression, purification, and mechanistic characterization of GDP-4-keto-6-deoxy-D-mannose-3-dehydrase (ColD) and GDP-L-colitose synthase (ColC).
L-Colitose is a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides. To study the biosynthesis of this… Expand
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2001
2001
Cloning and expression of Helicobacter pylori GDP-l-fucose synthesizing enzymes (GMD and GMER) in Saccharomyces cerevisiae.
Helicobacter pylori is a Gram-negative gastric pathogen causing diseases from mild gastric infections to gastric cancer. The… Expand
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