GDC 0941

Known as: GDC-0941, GDC0941 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2018
0102019952018

Papers overview

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2014
2014
The phosphatidylinositol 3′-kinase (PI3K) pathway is dysregulated in multiple myeloma (MM); we therefore tested a highly… (More)
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Highly Cited
2012
Highly Cited
2012
Combinations of MAP/ERK kinase (MEK) and phosphoinositide 3-kinase (PI3K) inhibitors have shown promise in preclinical cancer… (More)
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2011
2011
CONTEXT Phosphoinositide 3-kinase (PI3K) regulates the transcription factor hypoxia-inducible factor-1 (HIF-1) in thyroid… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE The class I phosphatidylinositol 3' kinase (PI3K) plays a major role in proliferation and survival in a wide variety of… (More)
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2010
2010
The phosphatidylinositol 3-kinase (PI3K) pathway is a major determinant of cell cycling and proliferation. Its deregulation, by… (More)
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Highly Cited
2009
Highly Cited
2009
Herceptin (trastuzumab) is the backbone of HER2-directed breast cancer therapy and benefits patients in both the adjuvant and… (More)
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Highly Cited
2009
Highly Cited
2009
The phosphatidylinositide 3-kinase pathway is frequently deregulated in human cancers and inhibitors offer considerable… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Oncogenic activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is prevalent in breast cancer and has… (More)
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2009
2009
3501 Background: The PI3K-PTEN-AKT signaling pathway is deregulated in a wide variety of cancers. GDC-0941 is a potent and… (More)
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Highly Cited
2008
Highly Cited
2008
Phosphatidylinositol-3-kinase (PI3K) is an important target in cancer due to the deregulation of the PI3K/ Akt signaling pathway… (More)
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