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While radiotherapy is a widely used treatment for many types of human cancer, problems of radio-resistance and side effects… Expand 12071Background: Nephrotoxicity is a major complication of platinum-based chemotherapy and ranges in incidence from 31-68%. The… Expand PURPOSE Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal… Expand Severe and recurrent cisplatin-induced acute kidney injury (AKI) as part of standard cancer therapy is a known risk factor for… Expand TPS4164Background: Local progression causes up to 30% of deaths from pancreatic cancer (PC) and is also a significant source of… Expand PURPOSE
To assess the safety of the superoxide dismutase mimetic GC4419 in combination with radiation and concurrent cisplatin… Expand Lung cancer, together with head and neck cancer, accounts for more than one-fourth of cancer deaths worldwide. New, non-toxic… Expand The first tenet of medicine, “primum non nocere” or “first, do no harm”, is not always compatible with oncological interventions… Expand Elderly cancer patients treated with ionizing radiation (IR) or chemotherapy experience more frequent and greater normal tissue… Expand To date no models exist to study MnSOD deficiency in human cells. To address this deficiency, we created a SOD2-null human cell… Expand