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3D Slicer as an image computing platform for the Quantitative Imaging Network.
TLDR
An overview of 3D Slicer is presented as a platform for prototyping, development and evaluation of image analysis tools for clinical research applications and the utility of the platform in the scope of QIN is illustrated. Expand
A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases.
TLDR
Omission of up-front WBRT does not seem to compromise length of survival in patients treated with RS for newly diagnosed brain metastases, and there was no survival difference comparing RS alone initially to RS + up- front W BRT. Expand
A multiinstitutional outcome and prognostic factor analysis of radiosurgery for resectable single brain metastasis.
TLDR
The RS in conjunction with WBRT for single brain metastasis can produce substantial functional survival, especially in patients with good performance status and without extracranial metastasis, which strongly suggest that a randomized trial to compare RS with surgery is warranted. Expand
O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.
TLDR
It is shown that alterations in cancer cell mitochondrial oxidative metabolism resulting in increased levels of O2⋅- and H2O2 are capable of disrupting intracellular iron metabolism, thereby selectively sensitizing non-small-cell lung cancer and glioblastoma cells to ascorbate through pro-oxidant chemistry involving redox-active labile iron and H 2O2. Expand
Globally Optimal Tumor Segmentation in PET-CT Images: A Graph-Based Co-segmentation Method
TLDR
The method simulates the clinical practice of delineating tumor simultaneously using both PET and CT, and is able to concurrently segment tumor from both modalities, achieving globally optimal solutions in low-order polynomial time by a single maximum flow computation. Expand
Optimal Multiple Surface Segmentation With Shape and Context Priors
TLDR
A novel approach to multi-object segmentation that incorporates both shape and context prior knowledge in a 3-D graph-theoretic framework to help overcome the stated challenges is reported. Expand
The role of FDG PET in management of neck metastasis from head-and-neck cancer after definitive radiation treatment.
TLDR
For patients who have no evidence of residual lymphadenopathy and a negative FDG PET scan 12 weeks after definitive radiation, neck dissection can be safely withheld, and further studies with longer follow-up are necessary to determine the appropriateness of withholding neck dissections. Expand
Benign meningiomas: primary treatment selection affects survival.
TLDR
Benign meningiomas are well managed by TE or SE+RT and atypical pathologic features predict a poorer outcome, suggesting possible benefit from more aggressive treatment. Expand
Long-term quality of life for surgical and nonsurgical treatment of head and neck cancer.
TLDR
As nonsurgical means of treating HNC have become more aggressive and surgical techniques have been more focused on function preservation and rehabilitation, the overall health-related quality of life resulting from these different approaches is similar. Expand
Curative radiotherapy for primary orbital lymphoma.
TLDR
Radiotherapy alone is a highly effective modality in the curative management of primary orbital lymphoma and the use of the lens-sparing technique did not influence the incidence of cataractogenesis, and it is recommended to recommend this approach whenever possible. Expand
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