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A compensatory mutation occurs when the fitness loss caused by one mutation is remedied by its epistatic interaction with a… Expand MutS and MutL are both required to activate downstream events in DNA mismatch repair. We examined the rate of dissociation of… Expand Replication of the Escherichia coli chromosome is initiated at a unique site, oriC. Concurrent initiation occurs at all oriC… Expand Genomic homogeneity is investigated for a broad base of DNA sequences in terms of dinucleotide relative abundance distances… Expand In E. coli, replication initiates at a genetically unique origin, oriC. Rapidly growing cells contain multiple oriC copies… Expand We have examined individual GATC sites throughout the E. coli genome for their kinetics of remethylation by dam methyltransferase… Expand In Escherichia coli the methylation of the adenine in the sequence 5'-GATC-3' is catalysed by the dam gene product, a DNA adenine… Expand DNA from the E. coli replicative origin binds with high affinity to outer membrane preparations. Specific binding regions are… Expand The DNA adenine methylase of E. coli methylates adenines at GATC sequences. Strains deficient in this methylase are transformed… Expand Methylation of GATC sites by the dam methylase is required for efficient initiation of DNA replication at the replication origin… Expand